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Information Journal Paper

Title

Ocular Dorzolamide Nanoliposomes for Prolonged IOP Reduction: in-vitro and in-vivo Evaluation in Rabbits

Pages

  205-212

Abstract

 Dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. The aim of this study is to develop ocular Dorzolamide HCl Nanoliposomes (DRZ – Nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. Nanoliposomes were prepared using Reverse-phase evaporation vesicle (REV) and thin layer hydration (TLH) method with 7: 3 and 7: 4 molar ratios of phosphatidy lcholine: cholesterol. The physicochemical properties of the formulations were investigated. Formulations with 7: 4 lipid ratios were evaluated in terms of drug release, physical stability and ex-vivo permeation through the excised albino rabbit cornea. The rabbits in groups of 6 were treated with selected DRZ – Nanoliposomes or Dorzolamide solution or marketed dorzolamid preparation (Biosopt® ) and Intraocular pressure (IOP) was monitored. Formulations with 7: 4 molar ratio entrapped greater amount of drug compared to those with 7: 3 lipid components ratio. DRZ – Nanoliposomes with 7: 4 lipid ratio showed more transcorneal permeation than Dorzolamide solution (p<0. 05); and the formulation prepared by TLH method exhibited higher permeability than that prepared by REV method (p<0. 05). The selected DRZ – Nanoliposomes showed greater IOP lowering activity and a more prolonged effect compared to Dorzolamide solution and Biosopt® . DRZ – Nanoliposomes prepared by TLH method with 7: 4 ratios showed promising results as a candidate for the treatment of ocular hypertension.

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    APA: Copy

    KOUCHAK, MARYAM, Bahmandar, Reza, BAVARSAD, NEDA, & FARRAHI, FEREYDOUN. (2016). Ocular Dorzolamide Nanoliposomes for Prolonged IOP Reduction: in-vitro and in-vivo Evaluation in Rabbits. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 205-212. SID. https://sid.ir/paper/288530/en

    Vancouver: Copy

    KOUCHAK MARYAM, Bahmandar Reza, BAVARSAD NEDA, FARRAHI FEREYDOUN. Ocular Dorzolamide Nanoliposomes for Prolonged IOP Reduction: in-vitro and in-vivo Evaluation in Rabbits. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):205-212. Available from: https://sid.ir/paper/288530/en

    IEEE: Copy

    MARYAM KOUCHAK, Reza Bahmandar, NEDA BAVARSAD, and FEREYDOUN FARRAHI, “Ocular Dorzolamide Nanoliposomes for Prolonged IOP Reduction: in-vitro and in-vivo Evaluation in Rabbits,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 205–212, 2016, [Online]. Available: https://sid.ir/paper/288530/en

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