Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents

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El serwy Walaa S.; Mohamed Neama A.; M.Kassem Emad M.; Mahmoud Khaled; Mounier m.m.

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Information Journal Paper

Title

Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents

Author(s)

Keywords

Cytotoxic activity

Benzoxazin

Quinazolin

Antitumor

Docking analysis

Abstract

Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-Benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e. g., hydrazine hydrate and formamide. Some of the newly synthesized analogues were chosen to evaluate their Cytotoxic activity against human carcinoma cell lines (HePG2– MCF7– A549). The docking and the Cytotoxic activity results revealed that nearly all of the compounds containing N-phenyl aniline showed significant inhibition for the three cell lines.

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APA: Copy

El serwy, Walaa S., Mohamed, Neama A., M.Kassem, Emad M., Mahmoud, Khaled, & Mounier, m.m.. (2016). Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 179-196. SID. https://sid.ir/paper/288535/en

Vancouver: Copy

El serwy Walaa S., Mohamed Neama A., M.Kassem Emad M., Mahmoud Khaled, Mounier m.m.. Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):179-196. Available from: https://sid.ir/paper/288535/en

IEEE: Copy

Walaa S. El serwy, Neama A. Mohamed, Emad M. M.Kassem, Khaled Mahmoud, and m.m. Mounier, “Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 179–196, 2016, [Online]. Available: https://sid.ir/paper/288535/en

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