Development of a Curcumin Bioadhesive Monolithic Tablet for Treatment of Vaginal Candidiasis

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Hani Umme; SHIVAKUMAR H.G.; M.Osmani Riyaz Ali; Srivastava Atul; Kumar Varma Naga Sravan

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:1 Page(s): 23-34

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Title

Development of a Curcumin Bioadhesive Monolithic Tablet for Treatment of Vaginal Candidiasis

Author(s)

Keywords

Curcumin

Bioadhesion

Vaginal tablets

Candidiasis

Abstract

The present investigation was designed to formulate a natural tablet for the treatment of vaginal Candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive Curcumin Vaginal tablets were prepared by direct compression with different ratios of biadhesive polymers like xanthan gum, guar gum and HPMC. Curcumin tablets were characterized by studies of friability, hardness, hydration, DSC, mucoadhesion, In-vitro release and antifungal activity. DSC and FT-IR data indicate there was no interaction between the drug and the excipients and also polymer concentration has some effects on melting point of Curcumin. Formulation F3 showed the best results in terms of swelling and mucoadhesion together with prolonged drug release. The antifungal activity of the Curcumin tablet has demonstrated a significant effect against Candida albicans. Hence, the study indicates the possible and effective use of Curcumin bioadhesive monolithic vaginal tablet for vaginal Candidiasis as a promising natural antifungal treatment.

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APA: Copy

Hani, Umme, SHIVAKUMAR, H.G., M.Osmani, Riyaz Ali, Srivastava, Atul, & Kumar Varma, Naga Sravan. (2016). Development of a Curcumin Bioadhesive Monolithic Tablet for Treatment of Vaginal Candidiasis. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 23-34. SID. https://sid.ir/paper/288542/en

Vancouver: Copy

Hani Umme, SHIVAKUMAR H.G., M.Osmani Riyaz Ali, Srivastava Atul, Kumar Varma Naga Sravan. Development of a Curcumin Bioadhesive Monolithic Tablet for Treatment of Vaginal Candidiasis. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):23-34. Available from: https://sid.ir/paper/288542/en

IEEE: Copy

Umme Hani, H.G. SHIVAKUMAR, Riyaz Ali M.Osmani, Atul Srivastava, and Naga Sravan Kumar Varma, “Development of a Curcumin Bioadhesive Monolithic Tablet for Treatment of Vaginal Candidiasis,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 23–34, 2016, [Online]. Available: https://sid.ir/paper/288542/en

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