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Information Journal Paper

Title

A 16 Month Survey of Cyclosporine Utilization Evaluation in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Pages

  331-339

Abstract

 Objectives: graft versus host disease (GVHD) is a life threatening reaction in the stem cell transplantation process. Nowadays cyclosporine is the most commonly utilized agent for GVHD prophylaxis and it has a major role in successful transplantation. cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optimal method of Administration. Conditions related to cyclosporine Administration and possible related adverse reactions observed closely in our patients with the aim of constructing a comprehensive practice guideline in the future. Patients and Methods: Allogeneic stem cell transplant recipients who have been taking cyclosporine were monitored during and after their hospitalization while recording all observations on predefined questionnaires on the basis of periodic clinical and laboratory examinations for a 16 month period. Results: Mean recorded duration of infusions was 1. 44 ± 0. 68 h and by twice daily Administration, means intravenous and oral dose was 101. 85 ± 22. 03 mg and 219. 28 ± 63. 9 mg, respectively. A mean CsA trough level after about 12 h of specified unique doses was 223 ± 65 ng/mL. We found hypertension, nephrotoxicity, neurotoxicity, hypertension, and dyslipidemia in about 14, 20, 48, and 94 percent of patients. Conclusions: This study proposed that permanent guidance of healthcare team according to a fixed and standard method of cyclosporine Administration routine with using efficient facilities and protocols would be helpful considerably for an optimal pharmacotherapy.

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    APA: Copy

    TAVAKOLI ARDAKANI, MARIA, Tafazoli, ali, MEHDIZADEH, MAHSHID, HAJIFATHALI, ABBAS, & DADASHZADEH, SIMIN. (2016). A 16 Month Survey of Cyclosporine Utilization Evaluation in Allogeneic Hematopoietic Stem Cell Transplant Recipients. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 331-339. SID. https://sid.ir/paper/288550/en

    Vancouver: Copy

    TAVAKOLI ARDAKANI MARIA, Tafazoli ali, MEHDIZADEH MAHSHID, HAJIFATHALI ABBAS, DADASHZADEH SIMIN. A 16 Month Survey of Cyclosporine Utilization Evaluation in Allogeneic Hematopoietic Stem Cell Transplant Recipients. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):331-339. Available from: https://sid.ir/paper/288550/en

    IEEE: Copy

    MARIA TAVAKOLI ARDAKANI, ali Tafazoli, MAHSHID MEHDIZADEH, ABBAS HAJIFATHALI, and SIMIN DADASHZADEH, “A 16 Month Survey of Cyclosporine Utilization Evaluation in Allogeneic Hematopoietic Stem Cell Transplant Recipients,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 331–339, 2016, [Online]. Available: https://sid.ir/paper/288550/en

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