Simultaneous Determination of Diosmin and Hesperidin in Pharmaceuticals by RPLC using Ionic Liquids as Mobile Phase Modifiers

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Szymanski Marcin; Mlynarek Daria; Szymanski Arkadiusz; Matlawska Irena

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:1 Page(s): 141-148

Download Full-Text

View:

265

Download:

264

Cites:

Information Journal Paper

Title

Simultaneous Determination of Diosmin and Hesperidin in Pharmaceuticals by RPLC using Ionic Liquids as Mobile Phase Modifiers

Author(s)

Szymanski Marcin | Mlynarek Daria | Szymanski Arkadiusz | Matlawska Irena | Issue Writer Certificate

Keywords

Diosmin

Hesperidin

Reverse-Phase Liquid Chromatography

Ionic liquids

Abstract

Diosmin and Hesperidin are natural flavonoid glycosides found in various plant materials, mainly in citrus fruits in different concentrations. Diosmin for pharmaceutical use is obtained mainly semi-synthetically from Hesperidin. Hesperidin often accompanies Diosmin as a natural impurity in different pharmaceutical formulations; therefore, a simple, fast and precise method for the simultaneous assay of Diosmin and Hesperidin in pharmaceutical formulations has been developed to control their contents. Chromatographic resolution was performed using a column with C-18 packing and the following mobile phase: methanol/water (45: 55, v/v) with 0. 025% added didecyldimethylammonium lactate, which significantly affects retention, shortening analysis time and having a positive impact on the symmetry of resulting chromatographic peaks. The method shows linearity between 2. 5 and 100 μ g/mL, high repeatability (0. 39 and 0. 42% for Diosmin and Hesperidin, respectively) and accuracy of 96 to 102% for both the assayed compounds. Intraday and interday precision of the new method were less than RSD% 1, 2. The limit of detection of the assayed compounds is 2. 5 and 1. 2 μ g/mL for Diosmin and Hesperidin, respectively. The method was tested on several pharmaceutical products available in Poland.

Cites

No record.

References

No record.

Cite

APA: Copy

Szymanski, Marcin, Mlynarek, Daria, Szymanski, Arkadiusz, & Matlawska, Irena. (2016). Simultaneous Determination of Diosmin and Hesperidin in Pharmaceuticals by RPLC using Ionic Liquids as Mobile Phase Modifiers. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 141-148. SID. https://sid.ir/paper/288553/en

Vancouver: Copy

Szymanski Marcin, Mlynarek Daria, Szymanski Arkadiusz, Matlawska Irena. Simultaneous Determination of Diosmin and Hesperidin in Pharmaceuticals by RPLC using Ionic Liquids as Mobile Phase Modifiers. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):141-148. Available from: https://sid.ir/paper/288553/en

IEEE: Copy

Marcin Szymanski, Daria Mlynarek, Arkadiusz Szymanski, and Irena Matlawska, “Simultaneous Determination of Diosmin and Hesperidin in Pharmaceuticals by RPLC using Ionic Liquids as Mobile Phase Modifiers,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 141–148, 2016, [Online]. Available: https://sid.ir/paper/288553/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops