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Information Journal Paper

Title

ANTIOXIDANT, ANTIMUTAGENIC, TANNING AND CALPAIN INDUCTION ACTIVITIES OF METHANOLIC EXTRACT OF TUNISIAN PLANT (MORICANDIA ARVENSIS)

Pages

  119-134

Abstract

 In this study, we investigate the potential of Moricandia arvensis methanol leaf extract (MeOHL) on CALPAIN activity, MELANIN biosynthesis and DNA mutagenicity. Cytotoxic effect and measurement of reactive oxygen species (ROS) induced by lucigenin in colorectal cells (BE) were also determined. In addition, the chemical analysis of the extract was also studied and the chemical profile illustrates its content in para- hydroxybenzoic acid (p -HBA), a glycosylated kampferol (GK), a glycosylated kampferol with Rhamnose (GKR) and 19 amino acids (AAs). Our results showed that MEOHL EXTRACT enhanced a significant cytotoxic (max of IP=89.23%) and antioxidant (max of IP=100%) activities. Furthermore, the tested extract stimulated CALPAIN activity and significantly increased the production of intra (46 mg/mL cells) and extracellular MELANIN content (12.5mg/mL). Using Ames assay, the extract exhibits a significant inhibition of mutagenicity induced by methy- methane- sulfonate (MMS) (76.32%) as well as 2-aminoanthracene (2-AA) (91%) in the Salmonella thyphimurium TA104 assay system.

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    APA: Copy

    SKANDRANI, INES, LELOUP, LUDOVIK, KOVACIC, HERVE, DIJOUX FRANCA, MARIE GENEVIEVE, GHEDIRA, KAMEL, & CHEKIR GHEDIRA, LEILA. (2017). ANTIOXIDANT, ANTIMUTAGENIC, TANNING AND CALPAIN INDUCTION ACTIVITIES OF METHANOLIC EXTRACT OF TUNISIAN PLANT (MORICANDIA ARVENSIS). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(SUPPLEMENT), 119-134. SID. https://sid.ir/paper/288563/en

    Vancouver: Copy

    SKANDRANI INES, LELOUP LUDOVIK, KOVACIC HERVE, DIJOUX FRANCA MARIE GENEVIEVE, GHEDIRA KAMEL, CHEKIR GHEDIRA LEILA. ANTIOXIDANT, ANTIMUTAGENIC, TANNING AND CALPAIN INDUCTION ACTIVITIES OF METHANOLIC EXTRACT OF TUNISIAN PLANT (MORICANDIA ARVENSIS). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(SUPPLEMENT):119-134. Available from: https://sid.ir/paper/288563/en

    IEEE: Copy

    INES SKANDRANI, LUDOVIK LELOUP, HERVE KOVACIC, MARIE GENEVIEVE DIJOUX FRANCA, KAMEL GHEDIRA, and LEILA CHEKIR GHEDIRA, “ANTIOXIDANT, ANTIMUTAGENIC, TANNING AND CALPAIN INDUCTION ACTIVITIES OF METHANOLIC EXTRACT OF TUNISIAN PLANT (MORICANDIA ARVENSIS),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. SUPPLEMENT, pp. 119–134, 2017, [Online]. Available: https://sid.ir/paper/288563/en

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