EVALUATION OF THE WOUND HEALING ACTIVITY OF A TRADITIONAL COMPOUND HERBAL PRODUCT USING RAT EXCISION WOUND MODEL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Jahandideh Maryam; HAJIMEHDIPOOR HOMA; MORTAZAVI SEYED ALIREZA; DEHPOUR AHMADREZA; HASSANZADEH GHOLAMREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:SUPPLEMENT Page(s): 153-163

Download Full-Text

View:

271

Download:

343

Cites:

Information Journal Paper

Title

EVALUATION OF THE WOUND HEALING ACTIVITY OF A TRADITIONAL COMPOUND HERBAL PRODUCT USING RAT EXCISION WOUND MODEL

Author(s)

Keywords

BOSWELLIA CARTERI

ALOE VERA

COMMIPHORA MYRRHA

WOUND HEALING

EXCISION WOUND MODEL

IRANIAN TRADITIONAL MEDICINE

Abstract

Iranian Traditional Medicine (ITM) manuscripts contain prescriptions that have long been used for healing of wounds. The present study evaluates the healing effect of a poly herbal paste (PHP), retrieved from ITM sources, containing ALOE VERA, COMMIPHORA MYRRHA and BOSWELLIA CARTERI using rat EXCISION WOUND MODEL.Excision wounds were induced in six groups consisting of six rats each. Group 1 received no treatment, while groups 2 and 6 received tetracycline ointment, Alpha ointment, PHP 40%, PHP 10% and paste base every day, respectively. The percentage of wound contraction on days 2, 7, 14 and 21 and histopathology parameters of healed wounds on 14th and 21st days were evaluated. Moreover, antioxidant activity of PHP was evaluated using DPPH method.There was a significant improvement in WOUND HEALING in PHP 10% group on the 7th day of the treatment (p<0.05). Moreover, the healing effect of PHP 10% was significantly greater than the control, tetracycline and paste base groups on the 2nd, 14th and 21st days (p<0.05). On day 14, PHP 40% showed significant healing effect compared to the control, tetracycline and paste base groups (p<0.05). Fewer inflammatory cells were observed in PHP 10%-treated animals and this group demonstrated better re-epithelialization with remarkable neovascularization. Besides, the PHP 10% formulation exhibited antioxidant activity.In vivoand histopathologic examinations showed considerable WOUND HEALING in PHP 10% group. This finding could probably be due to the antioxidant, anti-inflammatory and antimicrobial activities of phytoconstituents of A. vera, B. carteri and C. myrrha.

Cites

No record.

References

No record.

Cite

APA: Copy

Jahandideh, Maryam, HAJIMEHDIPOOR, HOMA, MORTAZAVI, SEYED ALIREZA, DEHPOUR, AHMADREZA, & HASSANZADEH, GHOLAMREZA. (2017). EVALUATION OF THE WOUND HEALING ACTIVITY OF A TRADITIONAL COMPOUND HERBAL PRODUCT USING RAT EXCISION WOUND MODEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(SUPPLEMENT), 153-163. SID. https://sid.ir/paper/288568/en

Vancouver: Copy

Jahandideh Maryam, HAJIMEHDIPOOR HOMA, MORTAZAVI SEYED ALIREZA, DEHPOUR AHMADREZA, HASSANZADEH GHOLAMREZA. EVALUATION OF THE WOUND HEALING ACTIVITY OF A TRADITIONAL COMPOUND HERBAL PRODUCT USING RAT EXCISION WOUND MODEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(SUPPLEMENT):153-163. Available from: https://sid.ir/paper/288568/en

IEEE: Copy

Maryam Jahandideh, HOMA HAJIMEHDIPOOR, SEYED ALIREZA MORTAZAVI, AHMADREZA DEHPOUR, and GHOLAMREZA HASSANZADEH, “EVALUATION OF THE WOUND HEALING ACTIVITY OF A TRADITIONAL COMPOUND HERBAL PRODUCT USING RAT EXCISION WOUND MODEL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. SUPPLEMENT, pp. 153–163, 2017, [Online]. Available: https://sid.ir/paper/288568/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops