مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

BLACK SEED (NIGELLA SATIVA) AND ITS CONSTITUENT THYMOQUINONE AS AN ANTIDOTE OR A PROTECTIVE AGENT AGAINST NATURAL OR CHEMICAL TOXICITIES

Pages

  2-23

Abstract

 NIGELLA SATIVA (N. sativa), which belongs to the botanical family of Ranunculaceae, is a widely used medicinal plant all over the world. N. sativa seeds and oil have been used in the treatment of different diseases. Various studies on N. sativa have been carried out and a broad spectrum of its pharmacological actions have been established which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-i nflammatory, spasmolytic, and bronchodilator. This is also indicated that the majority of the therapeutic effects of N. sativa are due to the presence of THYMOQUINONE (TQ) that is the main bioactive constituent of the essential oil. According to several lines of evidence, the PROTECTIVE effects of this plant and its main constituent in different tissues including brain, heart, liver, kidney, and lung have been proved against some toxic agents either natural or CHEMICAL TOXINs in animal studies. In this review article, several in-vitro and animal studies in scientific databases which investigate the antidotal and PROTECTIVE effects of N. sativa and its main constituents against natural and chemical induced toxicities are introduced. Because human reports are rare, further studies are required to determine the efficacy of this plant as an ANTIDOTE or PROTECTIVE agent in human intoxication.

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    • Cite

    APA: Copy

    TAVAKKOLI, ALIREZA, AHMADI, ALI, RAZAVI, BIBI MARJAN, & HOSSEINZADEH, HOSSEIN. (2017). BLACK SEED (NIGELLA SATIVA) AND ITS CONSTITUENT THYMOQUINONE AS AN ANTIDOTE OR A PROTECTIVE AGENT AGAINST NATURAL OR CHEMICAL TOXICITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(SUPPLEMENT), 2-23. SID. https://sid.ir/paper/288577/en

    Vancouver: Copy

    TAVAKKOLI ALIREZA, AHMADI ALI, RAZAVI BIBI MARJAN, HOSSEINZADEH HOSSEIN. BLACK SEED (NIGELLA SATIVA) AND ITS CONSTITUENT THYMOQUINONE AS AN ANTIDOTE OR A PROTECTIVE AGENT AGAINST NATURAL OR CHEMICAL TOXICITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(SUPPLEMENT):2-23. Available from: https://sid.ir/paper/288577/en

    IEEE: Copy

    ALIREZA TAVAKKOLI, ALI AHMADI, BIBI MARJAN RAZAVI, and HOSSEIN HOSSEINZADEH, “BLACK SEED (NIGELLA SATIVA) AND ITS CONSTITUENT THYMOQUINONE AS AN ANTIDOTE OR A PROTECTIVE AGENT AGAINST NATURAL OR CHEMICAL TOXICITIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. SUPPLEMENT, pp. 2–23, 2017, [Online]. Available: https://sid.ir/paper/288577/en

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