Comparison of Dabigatran vs. Warfarin in Acute Vnous Thromboemboly: Systematic Review

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Ganji reza; ALA SHAHRAM; AARABI MOHSEN; Baghery Babak; SALEHIFAR EBRAHIM

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:2 Page(s): 611-617

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Title

Comparison of Dabigatran vs. Warfarin in Acute Vnous Thromboemboly: Systematic Review

Author(s)

Keywords

Dabigatran

Warfarin

Venous Thromboembolism

direct oral anticoagulants

VTE

Abstract

Acute Venous Thromboembolism (VTE) is a common disease associated with the significant morbidity and mortality. We reviewed clinical outcomes systematically with Dabigatran as a direct oral anticoagulants (DOAC) for treatment of acute VTE. We used Ovide, PubMed, Cochrane (CENTRAL), EMBASE, Scopus, Science Direct, LILAC(for article written not English) and also Iranian database; Magiran, Isc, Iran Medex, Iran DOC, Doaj up to May 2014 to identify randomized clinical trials of Dabigatran compared with conventional treatment for VTE. Two investigators extracted data independently. Number of 5107 patients including two trails were selected. The risk of recurrent VTE was similar with the Dabigatran and standard treatment (Hazard Ratio, 95% confidence interval 1. 09 (0. 76-1. 57). Dabigatran reduced the risk of minor bleeding in comparison with standard treatment; Warfarin (0. 62) (0. 50-0. 76). Finally-in minor bleeding-the Dabigatran seemed as effective as, and probably safer than standard treatment of acute VTE. But in some aspects such as adherence to treatment, pregnant patient, impact on quality of life, new researches are needed to be clarified.

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APA: Copy

Ganji, reza, ALA, SHAHRAM, AARABI, MOHSEN, Baghery, Babak, & SALEHIFAR, EBRAHIM. (2016). Comparison of Dabigatran vs. Warfarin in Acute Vnous Thromboemboly: Systematic Review. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(2), 611-617. SID. https://sid.ir/paper/288609/en

Vancouver: Copy

Ganji reza, ALA SHAHRAM, AARABI MOHSEN, Baghery Babak, SALEHIFAR EBRAHIM. Comparison of Dabigatran vs. Warfarin in Acute Vnous Thromboemboly: Systematic Review. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(2):611-617. Available from: https://sid.ir/paper/288609/en

IEEE: Copy

reza Ganji, SHAHRAM ALA, MOHSEN AARABI, Babak Baghery, and EBRAHIM SALEHIFAR, “Comparison of Dabigatran vs. Warfarin in Acute Vnous Thromboemboly: Systematic Review,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 2, pp. 611–617, 2016, [Online]. Available: https://sid.ir/paper/288609/en

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