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Information Journal Paper

Title

In-Vitro Characterization and Oral Bioavailability of Organic Solvent-free Solid Dispersions Containing Telmisartan

Pages

  385-394

Abstract

 Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, Organic Solvent-free Solid dispersions (OSF-SDs) containing Telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and poloxamer 188 as a surfactant by a lyophilization method. In-vitro dissolution rate and physicochemical properties of the OSF-SDs were characterized using the USP I basket method, differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and fourier transform-infrared (FT-IR) spectroscopy. In addition, the Oral bioavailability of OSF-SDs in rats was evaluated by using TEL bulk powder as a reference. The dissolution rates of the OSF-SDs were significantly enhanced as compared to TEL bulk powder. The results from DSC, XRD showed that TEL was molecularly dispersed in the OSF-SDs as an amorphous form. The FT-IR results suggested that intermolecular hydrogen bonding had formed between TEL and its carriers. The OSF-SDs exhibited significantly higher AUC0– 24 h and Cmax, but similar Tmax as compared to the reference. This study demonstrated that OSF-SDs can be a promising method to enhance the dissolution rate and Oral bioavailability of TEL.

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    APA: Copy

    Cao, Yue, Shi, Li Li, Cao, Qing Ri, Yang, Mingshi, & Cui, Jing Hao. (2016). In-Vitro Characterization and Oral Bioavailability of Organic Solvent-free Solid Dispersions Containing Telmisartan. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(2), 385-394. SID. https://sid.ir/paper/288631/en

    Vancouver: Copy

    Cao Yue, Shi Li Li, Cao Qing Ri, Yang Mingshi, Cui Jing Hao. In-Vitro Characterization and Oral Bioavailability of Organic Solvent-free Solid Dispersions Containing Telmisartan. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(2):385-394. Available from: https://sid.ir/paper/288631/en

    IEEE: Copy

    Yue Cao, Li Li Shi, Qing Ri Cao, Mingshi Yang, and Jing Hao Cui, “In-Vitro Characterization and Oral Bioavailability of Organic Solvent-free Solid Dispersions Containing Telmisartan,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 2, pp. 385–394, 2016, [Online]. Available: https://sid.ir/paper/288631/en

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