Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats

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MANSOURI ESRAFIL; HARDANI AMENEH; AFZALZADEH MOHAMMAD REZA; AMIR ZARGAR ASHRAF; MEAMAR ZAKIEH

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:2 Page(s): 583-589

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Title

Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats

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Keywords

Diabetic ulcer

Rosa damascene

Retinoic acid

Abstract

Retinoic acid and Rosa damascena are compounds that have considerable effects in the cellular proliferation and synthesis of extracellular matrix. The present study was designed to assess the combined effects of Retinoic acid and Rosa damascena mill on wound in diabetic rats. Seventy-two rats were used in this study. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg. Kg-1). Then, a full thickness wound was created on dorsal surface of all animals. After that, rats were divided, into three groups; control (normal saline), positive control (Phenytoin), and case (combined of 0. 1% Tretinoein lotion and hydroalcoholic extract of Rosa damascena mill). Afterward, wounds were evaluated macroscopically and microscopically on days 5, 10 and 15. Macroscopic and microscopic evaluations showed a significant improvement (p<0. 05) of wounds in case group on 5th and 10th days when compared to positive control and control groups. The combination of Retinoic acid and hydro-alcholic extract of Rosa damascena mill can accelerate wound healing in diabetic rats.

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APA: Copy

MANSOURI, ESRAFIL, HARDANI, AMENEH, AFZALZADEH, MOHAMMAD REZA, AMIR ZARGAR, ASHRAF, & MEAMAR, ZAKIEH. (2016). Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(2), 583-589. SID. https://sid.ir/paper/288637/en

Vancouver: Copy

MANSOURI ESRAFIL, HARDANI AMENEH, AFZALZADEH MOHAMMAD REZA, AMIR ZARGAR ASHRAF, MEAMAR ZAKIEH. Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(2):583-589. Available from: https://sid.ir/paper/288637/en

IEEE: Copy

ESRAFIL MANSOURI, AMENEH HARDANI, MOHAMMAD REZA AFZALZADEH, ASHRAF AMIR ZARGAR, and ZAKIEH MEAMAR, “Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 2, pp. 583–589, 2016, [Online]. Available: https://sid.ir/paper/288637/en

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