Reinvestigation of the Two-step Synthesis of Sevoflurane

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MOGHIMI ABOLGHASEM; VOJDANI MOSTAFA; Banan Ali R.; Mollaei Ahmad; Mahmoodian Mojtaba; Moosavi Sayyed Mojtaba

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:3 Page(s): 733-738

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Title

Reinvestigation of the Two-step Synthesis of Sevoflurane

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Keywords

Inhalation anesthetic;Sevoflurane;Halogen

exchange fluorination;Hexafluoro

propanol

Abstract

Improvements in the two-step synthesis of 1, 1, 1, 3, 3, 3-hexafluoro-2-(fluoromehoxy)propane (Sevoflurane) that result in the product cost reduction, safety level enhancement and positive environmental impacts are described. This process consists of chloromethylation reaction of 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol (HFIP) followed by a halogen-exchange fluorination. This is the first synthesis of Sevoflurane in Iran which was successfully scaled up. During this work, several improvements have been achieved by optimization of the reaction time, the amount of consumed starting materials and solvents and work up procedure while keeping the yield and purity intact. The reaction time of the first step (24 h) was diminished to 4 h. 19F NMR spectroscopy was used to investigate the rate of the reaction in the first step and to evaluate the influence of different parameters mentioned on the achieved improvements.

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APA: Copy

MOGHIMI, ABOLGHASEM, VOJDANI, MOSTAFA, Banan, Ali R., Mollaei, Ahmad, Mahmoodian, Mojtaba, & Moosavi, Sayyed Mojtaba. (2015). Reinvestigation of the Two-step Synthesis of Sevoflurane. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(3), 733-738. SID. https://sid.ir/paper/288657/en

Vancouver: Copy

MOGHIMI ABOLGHASEM, VOJDANI MOSTAFA, Banan Ali R., Mollaei Ahmad, Mahmoodian Mojtaba, Moosavi Sayyed Mojtaba. Reinvestigation of the Two-step Synthesis of Sevoflurane. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(3):733-738. Available from: https://sid.ir/paper/288657/en

IEEE: Copy

ABOLGHASEM MOGHIMI, MOSTAFA VOJDANI, Ali R. Banan, Ahmad Mollaei, Mojtaba Mahmoodian, and Sayyed Mojtaba Moosavi, “Reinvestigation of the Two-step Synthesis of Sevoflurane,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 3, pp. 733–738, 2015, [Online]. Available: https://sid.ir/paper/288657/en

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