APPLICATION OF GUANIDINE HCL TO IMPROVE ENANTIOSEPARATION OF A MODEL BASIC DRUG, CETIRIZINE, BY CAPILLARY ELECTROPHORESIS USING SULFATED Β-CYCLODEXTRIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAFAATI ALIREZA; ZARGHI AFSHIN; SATTARY JAVID FARIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:2 Page(s): 505-512

Download Full-Text

View:

275

Download:

195

Cites:

Information Journal Paper

Title

APPLICATION OF GUANIDINE HCL TO IMPROVE ENANTIOSEPARATION OF A MODEL BASIC DRUG, CETIRIZINE, BY CAPILLARY ELECTROPHORESIS USING SULFATED Β-CYCLODEXTRIN

Author(s)

SHAFAATI ALIREZA | ZARGHI AFSHIN | SATTARY JAVID FARIN | Issue Writer Certificate

Keywords

CETIRIZINE

CHIRAL SEPARATION

CAPILLARY ELECTROPHORESIS

GUANIDINE HCL

SULFATED β-CYCLODEXTRIN

Abstract

A common approach in resolving enantiomers of chiral basic drugs by CAPILLARY ELECTROPHORESIS (CE) is to use cyclodextrins (especially their anionic derivatives) as chiralselector in the acidic buffer (pH£3) in normal or reversed (carrier) mode. Then, some organic modifiers are added to the buffer solution if the resolution is not satisfactory. In case of CETIRIZINE (CTN), applying the same approach, i.e. a reversed mode capillary zone electrophoresis (CZE) method with an acidic buffer and sulfated-b-cyclodextrine (S-bCD) as chiral selector, was failed and no complete enantioseparation was achieved. Different organic modifiers, like urea and triethylamine HCl, were used to improve chiral resolution which led to partial resolution of the two peaks. Then, GUANIDINE HCL at a concnetration of 100 mM was added to the running buffer and an acceptable resolution of the enantiomers of the drug was obtained. The method was successfully applied to determine optical purity of a levo -CETIRIZINE (l-CTN) sample.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAFAATI, ALIREZA, ZARGHI, AFSHIN, & SATTARY JAVID, FARIN. (2018). APPLICATION OF GUANIDINE HCL TO IMPROVE ENANTIOSEPARATION OF A MODEL BASIC DRUG, CETIRIZINE, BY CAPILLARY ELECTROPHORESIS USING SULFATED ?-CYCLODEXTRIN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(2), 505-512. SID. https://sid.ir/paper/288710/en

Vancouver: Copy

SHAFAATI ALIREZA, ZARGHI AFSHIN, SATTARY JAVID FARIN. APPLICATION OF GUANIDINE HCL TO IMPROVE ENANTIOSEPARATION OF A MODEL BASIC DRUG, CETIRIZINE, BY CAPILLARY ELECTROPHORESIS USING SULFATED ?-CYCLODEXTRIN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(2):505-512. Available from: https://sid.ir/paper/288710/en

IEEE: Copy

ALIREZA SHAFAATI, AFSHIN ZARGHI, and FARIN SATTARY JAVID, “APPLICATION OF GUANIDINE HCL TO IMPROVE ENANTIOSEPARATION OF A MODEL BASIC DRUG, CETIRIZINE, BY CAPILLARY ELECTROPHORESIS USING SULFATED ?-CYCLODEXTRIN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 2, pp. 505–512, 2018, [Online]. Available: https://sid.ir/paper/288710/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops