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Information Journal Paper

Title

PRECLINICAL EVALUATION OF 68GA-MAA FROM COMMERCIAL AVAILABLE 99MTC- MAA KIT

Pages

  1415-1423

Abstract

 99mTc-Macroaggregated Albumin (99mTc-MAA) has been used as a perfusion agent. This study described development of the 68Ga-MAA via commercially available kits from Pars- Isotopes Company as a 99mTc-MAA kit. 68Ge/68Ga generator was eluted with suprapure HCl (0.6 M, 6 mL) in 0.5 mL fractions. The two fractions with the highest 68GaCl3 activity were generally used for labeling purposes. After labeling, the final product was centrifuged 2 times to purify the solution. Five rats were sacrificed at each exact time interval (from 15 min to 2 h post injection) and the percentage of injected dose per gram (%ID/g) of each organ was measured by direct counting from 11 harvested organs of rats. The RTLC showed that labeling yields before centrifuges were 90% and 95% for Pars- Isotopes and GE kits, respectively and after centrifuges, they became 100%. The microscopic size examination showed a shift in the particle sizes post centrifuges and the bio distribution data revealed the efficiency and benefits of centrifuges in terms of preventing the of liver and bone marrow uptakes especially for Pars-Isotopes kits. Our results showed that after centrifuges of the final product, the lung uptakes increased from 89% to more than 97% of %ID/g after 5 min post injections. The whole procedure took less than 25 min from elution to the final product. Since 99mTc-MAA remained longer than 68Ga-MAA in the lung and 68Ga-MAA showed better image qualities, using 68Ga-MAA is recommended.

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    APA: Copy

    SHANEHSAZZADEH, SAEED, JALILIAN, AMIR REZA, LAHOOTI, AFSANEH, GERAMIFAR, PARHAM, BEIKI, DAVOOD, YOUSEFNIA, HASSAN, RABIEE, AMIR, MAZIDI, MOHAMMAD, MIRSHOJAEI, SEYEDEH FATEMEH, & MAUS, STEPHAN. (2017). PRECLINICAL EVALUATION OF 68GA-MAA FROM COMMERCIAL AVAILABLE 99MTC- MAA KIT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1415-1423. SID. https://sid.ir/paper/288715/en

    Vancouver: Copy

    SHANEHSAZZADEH SAEED, JALILIAN AMIR REZA, LAHOOTI AFSANEH, GERAMIFAR PARHAM, BEIKI DAVOOD, YOUSEFNIA HASSAN, RABIEE AMIR, MAZIDI MOHAMMAD, MIRSHOJAEI SEYEDEH FATEMEH, MAUS STEPHAN. PRECLINICAL EVALUATION OF 68GA-MAA FROM COMMERCIAL AVAILABLE 99MTC- MAA KIT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1415-1423. Available from: https://sid.ir/paper/288715/en

    IEEE: Copy

    SAEED SHANEHSAZZADEH, AMIR REZA JALILIAN, AFSANEH LAHOOTI, PARHAM GERAMIFAR, DAVOOD BEIKI, HASSAN YOUSEFNIA, AMIR RABIEE, MOHAMMAD MAZIDI, SEYEDEH FATEMEH MIRSHOJAEI, and STEPHAN MAUS, “PRECLINICAL EVALUATION OF 68GA-MAA FROM COMMERCIAL AVAILABLE 99MTC- MAA KIT,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1415–1423, 2017, [Online]. Available: https://sid.ir/paper/288715/en

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