ANTIBACTERIAL ACTIVITY OF ONOPORDUM ESPINAE: IDENTIFICATION OF HISPIDULIN AND DEHYDROMELITENSIN-8-(4ꞌ-HYDROXY- METHACRYLATE)

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NJEH FATMA; MHALLA DHEKRA; HAMMOUDA IBTISSEM BEN; TRIGUI MOHAMED; RAOUDHA MEZGHANI JARRAYA

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:4 Page(s): 1531-1537

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Information Journal Paper

Title

ANTIBACTERIAL ACTIVITY OF ONOPORDUM ESPINAE: IDENTIFICATION OF HISPIDULIN AND DEHYDROMELITENSIN-8-(4ꞌ-HYDROXY- METHACRYLATE)

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Keywords

TOTAL FLAVONOID CONTENT

TOTAL PHENOLIC CONTENT

DPPH RADICAL- SCAVENGING ASSAY

HISPIDULIN

DEHYDROMELITENSIN-8-(4ꞌ-HYDROXY- METHACRYLATE)

ANTIBACTERIAL ACTIVITY

Abstract

Hexane, ethyl acetate and methanol extracts of Onopordum espinae leaves were investigated for their antibacterial activities against Bacillus cereus, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Salmonella enteritidis. Hexane and ethyl acetate extracts were toxic to Gram- positive bacteria with inhibition zone diameters ranging between 12 and 30 mm. Two products, HISPIDULIN 1, and dehydromelitensin-8- (4ꞌ- hydroxy- methacrylate) 2 were isolated from the ethyl acetate extract of leaves and identified by 2D-NMR for the first time from this species. Ethyl acetate extractꞌs TOTAL FLAVONOID CONTENT was the highest, as 78.73 mg quercetin equivalents (QE)/ g. The methanol extract showed the highest TOTAL PHENOLIC CONTENT as 243.43 mg gallic acid equivalents (GAE)/ g and gave the most important 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity (EC50=86 mg/mL).

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APA: Copy

NJEH, FATMA, MHALLA, DHEKRA, HAMMOUDA, IBTISSEM BEN, TRIGUI, MOHAMED, & RAOUDHA, MEZGHANI JARRAYA. (2017). ANTIBACTERIAL ACTIVITY OF ONOPORDUM ESPINAE: IDENTIFICATION OF HISPIDULIN AND DEHYDROMELITENSIN-8-(4?-HYDROXY- METHACRYLATE). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1531-1537. SID. https://sid.ir/paper/288718/en

Vancouver: Copy

NJEH FATMA, MHALLA DHEKRA, HAMMOUDA IBTISSEM BEN, TRIGUI MOHAMED, RAOUDHA MEZGHANI JARRAYA. ANTIBACTERIAL ACTIVITY OF ONOPORDUM ESPINAE: IDENTIFICATION OF HISPIDULIN AND DEHYDROMELITENSIN-8-(4?-HYDROXY- METHACRYLATE). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1531-1537. Available from: https://sid.ir/paper/288718/en

IEEE: Copy

FATMA NJEH, DHEKRA MHALLA, IBTISSEM BEN HAMMOUDA, MOHAMED TRIGUI, and MEZGHANI JARRAYA RAOUDHA, “ANTIBACTERIAL ACTIVITY OF ONOPORDUM ESPINAE: IDENTIFICATION OF HISPIDULIN AND DEHYDROMELITENSIN-8-(4?-HYDROXY- METHACRYLATE),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1531–1537, 2017, [Online]. Available: https://sid.ir/paper/288718/en

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