مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

METHADONE CONCENTRATIONS IN EXHALED BREATH CONDENSATE, SERUM AND URINE OF PATIENTS UNDER MAINTENANCE TREATMENT

Pages

  1621-1630

Abstract

 Drug abuse is a serious problem causing health, economical and psycho-social negative outcomes. METHADONE is commonly used drug for management of drug addiction. EXHALED BREATH CONDENSATE (EBC) is a promising non- invasive biological sample which attracted more attention in recent years. This work aimed to extend the applicability of a developed preconcentration- liquid chromatographic method for analysis of METHADONE in SERUM and URINE samples. Drug concentrations in EBC, SERUM and URINE are also investigated for dose- concentration and their inter- CORRELATIONs. Biological samples were collected from 53 patients receiving METHADONE and the concentrations were determined using a validated analytical method after a pre- concentration step. METHADONE measured in all samples and there are CORRELATIONs between administered dose of METHADONE and its SERUM and URINE concentrations. A weak CORRELATION is observed between dose and EBC concentration. Wider variations in EBC concentrations of METHADONE could be justified concerning a number of affecting parameters such as relative humidity of the collection area and further investigations are required for standardization of EBC as a non-invasive biological sample to be used in clinical practice.

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    APA: Copy

    KHOUBNASAB JAFARI, MARYAM, ANSARIN, KHALIL, JOUYBAN GHARAMALEKI, VAHID, PANAHI AZAR, VAHID, HAMIDI, SAMIN, AZARMIR, ZHILA, & JOUYBAN, ABOLGHASEM. (2017). METHADONE CONCENTRATIONS IN EXHALED BREATH CONDENSATE, SERUM AND URINE OF PATIENTS UNDER MAINTENANCE TREATMENT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1621-1630. SID. https://sid.ir/paper/288723/en

    Vancouver: Copy

    KHOUBNASAB JAFARI MARYAM, ANSARIN KHALIL, JOUYBAN GHARAMALEKI VAHID, PANAHI AZAR VAHID, HAMIDI SAMIN, AZARMIR ZHILA, JOUYBAN ABOLGHASEM. METHADONE CONCENTRATIONS IN EXHALED BREATH CONDENSATE, SERUM AND URINE OF PATIENTS UNDER MAINTENANCE TREATMENT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1621-1630. Available from: https://sid.ir/paper/288723/en

    IEEE: Copy

    MARYAM KHOUBNASAB JAFARI, KHALIL ANSARIN, VAHID JOUYBAN GHARAMALEKI, VAHID PANAHI AZAR, SAMIN HAMIDI, ZHILA AZARMIR, and ABOLGHASEM JOUYBAN, “METHADONE CONCENTRATIONS IN EXHALED BREATH CONDENSATE, SERUM AND URINE OF PATIENTS UNDER MAINTENANCE TREATMENT,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1621–1630, 2017, [Online]. Available: https://sid.ir/paper/288723/en

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