CARBOPLATIN- BASED NANOMEDICINE TO ENHANCE THE ANTICANCER EFFECT IN SKNEP- 1 WILMSꞌ TUMOR CELLS

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MING MING; MA ZHAO LONG; XU YONG TAO; SUN FENG YIN; CUIA XIN HAI

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:4 Page(s): 1305-1311

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Title

CARBOPLATIN- BASED NANOMEDICINE TO ENHANCE THE ANTICANCER EFFECT IN SKNEP- 1 WILMSꞌ TUMOR CELLS

Author(s)

Keywords

CARBOPLATIN

APOPTOSIS

CELL PROLIFERATION

WILM'S TUMOR

ANTICANCER EFFECT

Abstract

Wilms tumor (WT) is the most common pediatric malignant primary renal tumor. CARBOPLATIN (CRB), a platinum compound is widely used in the treatment of multiple cancers including ovarian, lung, head and neck, and wilm’s tumor. However, lower uptake of CRB in cancer cells and toxicity concerns in healthy cells often limited its clinical outcome. The aim of this study was to investigate the antitumor effect of CRB on SK-NEP-1 wilm’s cancer cells. Earlier, CRB was formulated in nanoparticulate formulations and characterized its biophysical parameters. SK-NEP-1 cell growth in vitro was assessed by MTT. Then, APOPTOSIS potential was investigated by TUNEL, Hoechst, and colony formation assay. CRB treatment resulted in inhibition of CELL PROLIFERATION of SK-NEP-1cells in a dose-dependent manner. TUNEL, Hoechst, and colony formation assay demonstrated that CRB was more effective in killing wilm’s cancer cell when encapsulated in nanoparticle formulations. Overall, the present study demonstrates that CRB treatment resulted in marked inhibition of CELL PROLIFERATION and cell APOPTOSIS. These results may pave way for the effective treatment of wilm’s tumor in clinical models.

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APA: Copy

MING, MING, MA, ZHAO LONG, XU, YONG TAO, SUN, FENG YIN, & CUIA, XIN HAI. (2017). CARBOPLATIN- BASED NANOMEDICINE TO ENHANCE THE ANTICANCER EFFECT IN SKNEP- 1 WILMS? TUMOR CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1305-1311. SID. https://sid.ir/paper/288741/en

Vancouver: Copy

MING MING, MA ZHAO LONG, XU YONG TAO, SUN FENG YIN, CUIA XIN HAI. CARBOPLATIN- BASED NANOMEDICINE TO ENHANCE THE ANTICANCER EFFECT IN SKNEP- 1 WILMS? TUMOR CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1305-1311. Available from: https://sid.ir/paper/288741/en

IEEE: Copy

MING MING, ZHAO LONG MA, YONG TAO XU, FENG YIN SUN, and XIN HAI CUIA, “CARBOPLATIN- BASED NANOMEDICINE TO ENHANCE THE ANTICANCER EFFECT IN SKNEP- 1 WILMS? TUMOR CELLS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1305–1311, 2017, [Online]. Available: https://sid.ir/paper/288741/en

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