IMPACT OF ASPIRIN EUGENOL ESTER ON CYCLOOXYGENASE-1, CYCLOOXYGENASE-2, C-REACTIVE PROTEIN, PROTHROMBIN AND ARACHIDONATE 5-LIPOXYGENASE IN HEALTHY RATS

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MA NING; YANG GUAN ZHOU; LIUA XI WANG; YANG YA JUN; MOHAMED ISAM; LIU GUANG RONG; LI JIAN YONG

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:4 Page(s): 1443-1451

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Title

IMPACT OF ASPIRIN EUGENOL ESTER ON CYCLOOXYGENASE-1, CYCLOOXYGENASE-2, C-REACTIVE PROTEIN, PROTHROMBIN AND ARACHIDONATE 5-LIPOXYGENASE IN HEALTHY RATS

Author(s)

Keywords

ASPIRIN EUGENOL ESTER (AEE)

CHEMICAL- PROTEIN INTERACTIONS

THROMBOSIS

INFLAMMATION

RATS

Abstract

Aspirin eugenol ester (AEE) is a promising drug candidate which is used for the treatment of INFLAMMATION, pain, fever, and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to INFLAMMATION and THROMBOSIS, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidonate 5-lipoxygenase (ALOX5). Meanwhile, the study was administrated to compare the drug effect between AEE and its precursor from the view of chemical-protein interactions. Healthy RATS were given AEE, aspirin, eugenol and integration of aspirin and eugenol. Carboxyl methyl cellulose sodium (CMC-Na) was used as control. After drugs were administered intragastrically for seven days, the blood samples were collected to measure the proteins concentration by enzyme linked immuno- sorbent assay (ELISA). The results showed that the concentrations of key endogenic bioactive enzymes were significantly reduced in AEE groups when compared with CMC-Na and aspirin groups (P<0.01). Drug effects of AEE on five proteins were stronger than aspirin and eugenol. From the view of chemical-protein interactions, AEE had positive effects on anti- INFLAMMATION and anti-thrombosis and showed stronger effects than aspirin and eugenol.

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APA: Copy

MA, NING, YANG, GUAN ZHOU, LIUA, XI WANG, YANG, YA JUN, MOHAMED, ISAM, LIU, GUANG RONG, & LI, JIAN YONG. (2017). IMPACT OF ASPIRIN EUGENOL ESTER ON CYCLOOXYGENASE-1, CYCLOOXYGENASE-2, C-REACTIVE PROTEIN, PROTHROMBIN AND ARACHIDONATE 5-LIPOXYGENASE IN HEALTHY RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1443-1451. SID. https://sid.ir/paper/288743/en

Vancouver: Copy

MA NING, YANG GUAN ZHOU, LIUA XI WANG, YANG YA JUN, MOHAMED ISAM, LIU GUANG RONG, LI JIAN YONG. IMPACT OF ASPIRIN EUGENOL ESTER ON CYCLOOXYGENASE-1, CYCLOOXYGENASE-2, C-REACTIVE PROTEIN, PROTHROMBIN AND ARACHIDONATE 5-LIPOXYGENASE IN HEALTHY RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1443-1451. Available from: https://sid.ir/paper/288743/en

IEEE: Copy

NING MA, GUAN ZHOU YANG, XI WANG LIUA, YA JUN YANG, ISAM MOHAMED, GUANG RONG LIU, and JIAN YONG LI, “IMPACT OF ASPIRIN EUGENOL ESTER ON CYCLOOXYGENASE-1, CYCLOOXYGENASE-2, C-REACTIVE PROTEIN, PROTHROMBIN AND ARACHIDONATE 5-LIPOXYGENASE IN HEALTHY RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1443–1451, 2017, [Online]. Available: https://sid.ir/paper/288743/en

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