ANTI- INVASION EFFECTS OF CANNABINOIDS AGONIST AND ANTAGONIST ON HUMAN BREAST CANCER STEM CELLS

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MOHAMMADPOUR FATEMEH; OSTAD SEYED NASSER; ALIEBRAHIMI SHIMA; DAMAN ZAHRA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:4 Page(s): 1479-1486

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Information Journal Paper

Title

ANTI- INVASION EFFECTS OF CANNABINOIDS AGONIST AND ANTAGONIST ON HUMAN BREAST CANCER STEM CELLS

Author(s)

MOHAMMADPOUR FATEMEH | OSTAD SEYED NASSER | ALIEBRAHIMI SHIMA | DAMAN ZAHRA | Issue Writer Certificate

Keywords

AM251

BREAST CANCER STEM CELL

ACEA

MDA-MB-231

INVASION

CANNABINOIDS

Abstract

Studies show that cancer cell INVASION or metastasis is the primary cause of death in malignancies including breast cancer. The existence of cancer stem cells (CSCs) in breast cancer may account for tumor initiation, progression, and metastasis. Recent studies have reported different effects of CANNABINOIDS on cancer cells via CB1 and CB2 cannabinoid receptors. In the present study, the effects of ACEA (a selective CB1 receptor agonist) and AM251 (a selective CB1 antagonist) on CSCs and their parental cells were investigated. Breast CSCs derived from MDA-MB-231 cell line were sorted and characterized with CD44+/CD24-/low/ESA+phenotype. It was observed that ACEA decreased CD44+/CD24-/low/ESA+ cancer stem cell invasiveness. Conversely, AM251 increased the INVASION by more than 20% (at the highest concentrations) in both MDA-MB-231 and CSCs. Our results did not show any correlation between reduced INVASION and cytotoxic effects of the drug. Since one of the main cancer recurrence factors is anti- cancer drugs fail to inhibit CSC population, this observation would be useful for cancer treatment.

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APA: Copy

MOHAMMADPOUR, FATEMEH, OSTAD, SEYED NASSER, ALIEBRAHIMI, SHIMA, & DAMAN, ZAHRA. (2017). ANTI- INVASION EFFECTS OF CANNABINOIDS AGONIST AND ANTAGONIST ON HUMAN BREAST CANCER STEM CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1479-1486. SID. https://sid.ir/paper/288748/en

Vancouver: Copy

MOHAMMADPOUR FATEMEH, OSTAD SEYED NASSER, ALIEBRAHIMI SHIMA, DAMAN ZAHRA. ANTI- INVASION EFFECTS OF CANNABINOIDS AGONIST AND ANTAGONIST ON HUMAN BREAST CANCER STEM CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1479-1486. Available from: https://sid.ir/paper/288748/en

IEEE: Copy

FATEMEH MOHAMMADPOUR, SEYED NASSER OSTAD, SHIMA ALIEBRAHIMI, and ZAHRA DAMAN, “ANTI- INVASION EFFECTS OF CANNABINOIDS AGONIST AND ANTAGONIST ON HUMAN BREAST CANCER STEM CELLS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1479–1486, 2017, [Online]. Available: https://sid.ir/paper/288748/en

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