مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

THE SYNERGISTIC EFFECTS OF CELECOXIB AND SODIUM VALPROATE ON APOPTOSIS AND INVASIVENESS BEHAVIOR OF PAPILLARY THYROID CANCER CELL LINE IN-VITRO

Pages

  1008-1017

Abstract

 Metastasis to lymph nodes and distant organs is the main challenge in the treatment of PAPILLARY THYROID CANCER. In the current investigation, we aimed to evaluate the synergistic effects of CELECOXIB (CX) and SODIUM VALPROATE (VPA) against cell survival, invasiveness properties, and expression of metalloproteinase-2 and -9 (MMP-2 and MMP-9) in PAPILLARY THYROID CANCER cell line, B-CPAP cells. The effect of CX and VPA on B-CPAP cells viability and APOPTOSIS were investigated using MTT assay and annexin V/7-AAD flowcytometry, respectively. The effects of the drugs on invasiveness properties of B-CPAP cells and expression of MMP-2 and MMP-9 were evaluated using transwell assay and real time PCR, respectively. MTT assay showed that CX and VPA decreased viability of B-CPAP cells dose dependently (IC50 32.4 mM and 6.8 mM, respectively). Combination of CX (5 mM) and VPA (2.5 and 5 mM) increased APOPTOSIS, and reduced cell MIGRATION and INVASION of B-CPAP cell, synergistically. Real time PCR results showed that both CX (5 mM) and VPA (2.5 and 5 mM) reduced MMP-2 expression (P<0.05) but had no significant effects on the expression of MMP-9. Our findings suggest that CX and VPA synergistically increase APOPTOSIS and suppress MIGRATION and INVASION of B-CPAP cells through inhibition of MMP-2 expression.

Cites

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    • Cite

    APA: Copy

    FANIAN, MARYAM, BAHMANI, MAEDEH, MOZAFARI, MOJDEH, NADERI, SAMANEH, ALIZADEH ZAREIE, MARZIEH, OKHOVAT, MOHAMMAD ALI, SABERZADEH, JAMILEH, DEHSHAHRI, ALI, & TAKHSHID, MOHAMMAD ALI. (2018). THE SYNERGISTIC EFFECTS OF CELECOXIB AND SODIUM VALPROATE ON APOPTOSIS AND INVASIVENESS BEHAVIOR OF PAPILLARY THYROID CANCER CELL LINE IN-VITRO. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(3), 1008-1017. SID. https://sid.ir/paper/288756/en

    Vancouver: Copy

    FANIAN MARYAM, BAHMANI MAEDEH, MOZAFARI MOJDEH, NADERI SAMANEH, ALIZADEH ZAREIE MARZIEH, OKHOVAT MOHAMMAD ALI, SABERZADEH JAMILEH, DEHSHAHRI ALI, TAKHSHID MOHAMMAD ALI. THE SYNERGISTIC EFFECTS OF CELECOXIB AND SODIUM VALPROATE ON APOPTOSIS AND INVASIVENESS BEHAVIOR OF PAPILLARY THYROID CANCER CELL LINE IN-VITRO. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(3):1008-1017. Available from: https://sid.ir/paper/288756/en

    IEEE: Copy

    MARYAM FANIAN, MAEDEH BAHMANI, MOJDEH MOZAFARI, SAMANEH NADERI, MARZIEH ALIZADEH ZAREIE, MOHAMMAD ALI OKHOVAT, JAMILEH SABERZADEH, ALI DEHSHAHRI, and MOHAMMAD ALI TAKHSHID, “THE SYNERGISTIC EFFECTS OF CELECOXIB AND SODIUM VALPROATE ON APOPTOSIS AND INVASIVENESS BEHAVIOR OF PAPILLARY THYROID CANCER CELL LINE IN-VITRO,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 3, pp. 1008–1017, 2018, [Online]. Available: https://sid.ir/paper/288756/en

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