مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

227
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

200
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

SAFFRON INDUCED RELAXATION IN ISOLATED RAT AORTA VIA ENDOTHELIUM DEPENDENT AND INDEPENDENT MECHANISMS

Pages

  1018-1025

Abstract

 Crocus sativusL. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of SAFFRON have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by SAFFRON on ISOLATED RAT AORTA.To study the vasodilatory effects of SAFFRON aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were contracted by 10−6 M phenylephrine (PE) or KCl 80 mM. The vasodilatory effect of SAFFRON was also evaluated both on intact and denuded endothelium aortic rings. To study the role of nitric oxide and prostacyclin in relaxation induced by SAFFRON, aortic rings were incubated by L-NAME (10-6 M) and INDOMETHACIN (10-5 M) respectively for 20 min. SAFFRON induced relaxation in endothelium-intact aortic rings precontracted with PE in a concentration dependent manner. The obtained relaxation induced by the highest SAFFRON concentration in endothelium-intact aortic rings precontracted with KCl was less than that observed in endothelium-intact aortic rings precontracted with PE. The relaxant activity of SAFFRON was abolished by incubation of aortic rings with L-NAME but not in the presence of INDOMETHACIN. Also, the vasodilatory activity of SAFFRON was partially abolished in endothelium denuded aortic rings. SAFFRON induced relaxation in isolated rat aortic rings might be due particularly to its effect on endothelium via nitric oxide synthase pathway and partly due to the effect on vascular smooth muscle cells via L type voltage dependent calcium channels.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    RAZAVI, BIBI MARJAN, ALYASIN, ALI, HOSSEINZADEH, HOSSEIN, & IMENSHAHIDI, MOHSEN. (2018). SAFFRON INDUCED RELAXATION IN ISOLATED RAT AORTA VIA ENDOTHELIUM DEPENDENT AND INDEPENDENT MECHANISMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(3), 1018-1025. SID. https://sid.ir/paper/288761/en

    Vancouver: Copy

    RAZAVI BIBI MARJAN, ALYASIN ALI, HOSSEINZADEH HOSSEIN, IMENSHAHIDI MOHSEN. SAFFRON INDUCED RELAXATION IN ISOLATED RAT AORTA VIA ENDOTHELIUM DEPENDENT AND INDEPENDENT MECHANISMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(3):1018-1025. Available from: https://sid.ir/paper/288761/en

    IEEE: Copy

    BIBI MARJAN RAZAVI, ALI ALYASIN, HOSSEIN HOSSEINZADEH, and MOHSEN IMENSHAHIDI, “SAFFRON INDUCED RELAXATION IN ISOLATED RAT AORTA VIA ENDOTHELIUM DEPENDENT AND INDEPENDENT MECHANISMS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 3, pp. 1018–1025, 2018, [Online]. Available: https://sid.ir/paper/288761/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button