TOXICITY AND POTENTIAL PHARMACOLOGICAL ACTIVITIES IN THE PERSIAN GULF VENOMOUS SEA ANEMONE, STICHODACTYLA HADDONI

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOGHADASI ZIBA; JAMILI SHAHLA; SHAHBAZADEH DELAVAR; POOSHANG BAGHERI KAMRAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:3 Page(s): 940-955

Download Full-Text

View:

264

Download:

250

Cites:

Information Journal Paper

Title

TOXICITY AND POTENTIAL PHARMACOLOGICAL ACTIVITIES IN THE PERSIAN GULF VENOMOUS SEA ANEMONE, STICHODACTYLA HADDONI

Author(s)

MOGHADASI ZIBA | JAMILI SHAHLA | SHAHBAZADEH DELAVAR | POOSHANG BAGHERI KAMRAN | Issue Writer Certificate

Keywords

STICHODACTYLA HADDONI

VENOM

TOXICITY

ANALGESIC ACTIVITY

THE PERSIAN GULF SEA ANEMONE

Abstract

Numerous proteins and peptides in VENOMous marine animals are potentially active molecules with pharmacological properties. Particular condition of the Persian Gulf as a closed ecosystem is a good opportunity to study of biological activities and TOXICITY of VENOMous animals. In this study, STICHODACTYLA HADDONI (S. haddoni), a sea anemone, selected to tracing for possible pharmaceutical agents and toxicological characterization. Analgesic, edematogenic, dermonecrotic, LD50, phospholipase, and proteolytic activities of the VENOM were estimated. LD50 was recorded at 675 mg by intraperitoneal injection. Analgesic activitiy of crude VENOM on Balb/c mice at both 100 and 150 mg were dose dependent as a linear trend. Three folds increase of activity was seen at both 100 and 150 mg after 240 min comparing to activity of morphine at 200 mg. The crude VENOM at amount of 0.23 mg produced 50% hemolysis. The highest edematogenic activity was seen on Balb/c mice just two hours after injection for both 168 mg (157%) and 335 mg (247%). The crude VENOM at 675 mg made 4 mm inflammation area on rabbit skin after 3 h but the amount of 1000 μg induced 8 mm necrosis area. Potent ANALGESIC ACTIVITY of the VENOM was seen below its toxic dose that was very greater than the other sea anemones in the other geographical areas. The results indicate that a persistent edematogenic activity could be happened after envenomation. Instant potent edematogenic and rapid dermonecrotic activity were significant phenomena. HD50 at 0.23 mg indicates that a very potent hemolytic agent exists in the VENOM. The results would also be of high value to better management of envenomation. This study confirmed the great value of further studies on the Persian Gulf S. haddoni VENOM.

Cites

No record.

References

No record.

Cite

APA: Copy

MOGHADASI, ZIBA, JAMILI, SHAHLA, SHAHBAZADEH, DELAVAR, & POOSHANG BAGHERI, KAMRAN. (2018). TOXICITY AND POTENTIAL PHARMACOLOGICAL ACTIVITIES IN THE PERSIAN GULF VENOMOUS SEA ANEMONE, STICHODACTYLA HADDONI. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(3), 940-955. SID. https://sid.ir/paper/288767/en

Vancouver: Copy

MOGHADASI ZIBA, JAMILI SHAHLA, SHAHBAZADEH DELAVAR, POOSHANG BAGHERI KAMRAN. TOXICITY AND POTENTIAL PHARMACOLOGICAL ACTIVITIES IN THE PERSIAN GULF VENOMOUS SEA ANEMONE, STICHODACTYLA HADDONI. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(3):940-955. Available from: https://sid.ir/paper/288767/en

IEEE: Copy

ZIBA MOGHADASI, SHAHLA JAMILI, DELAVAR SHAHBAZADEH, and KAMRAN POOSHANG BAGHERI, “TOXICITY AND POTENTIAL PHARMACOLOGICAL ACTIVITIES IN THE PERSIAN GULF VENOMOUS SEA ANEMONE, STICHODACTYLA HADDONI,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 3, pp. 940–955, 2018, [Online]. Available: https://sid.ir/paper/288767/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops