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Information Journal Paper

Title

PHYTONIOSOME: A NOVEL DRUG DELIVERY FOR MYRTLE EXTRACT

Pages

  804-817

Abstract

 Traditionally, MYRTUS COMMUNIS (myrtle) has been used for treatment of several kinds of disorders. However, there are some factors, namely, low solubility and permeability, which restrict use of MYRTLE extract (ME) in medical applications. Regarding these limitations, the aim of the present study was to develop a new niosomal formulation to enhance ME STABILITY and permeability. Briefly, several niosomal formulations were prepared by non-ionic surfactants and cholesterol with different molar ratios. Afterward, size, entrapment efficiency (EE%), RELEASE and STABILITY of niosomal MYRTLE extract (nME) were investigated. The effect of ME and nME on viability of 3T3 cells was evaluated using MTT assay. Antibacterial activity of ME and nME was also assessed against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Micrococcus luteus, and Bacillus subtilis. Sizes of niosomes were 5.3±0.3 to 15.9±2.2 mm with 4.1±0.3 to 26.9±1.7 mV zeta potential. The EE% of niosomes was varied from 45.4% to 93.4%. An in-vitro RELEASE study on F5 formulation (Span60: Tween60: cholesterol (3: 3: 4 molar ratio)) revealed that about 36.9%, 38.5% and 26.7% of phytoconstituents were RELEASEd within 12 h from acetate cellulose membrane, 0.45 μm, regenerated cellulose membrane, 0.45 μm, and cellophane dialysis sack, 12000 Da, respectively. F5 formulation significantly showed lower toxicity on cells. It had higher antibacterial activity that has been shown by lower MICs and higher zone of inhibition compared to ME.Overall, F5 formulation in the presence of 4% ME produced stable multi lamellar vesicles with optimalin-vitro RELEASE and EE%. This formulation also exhibited better antibacterial activity than ME.

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    • Cite

    APA: Copy

    RAEISZADEH, MAHBOOBEH, PARDAKHTY, ABBAS, SHARIFIFAR, FARIBA, MEHRABANI, MEHRNAZ, NEJAT MEHRAB KERMANI, HOJJAT, & MEHRABANI, MITRA. (2018). PHYTONIOSOME: A NOVEL DRUG DELIVERY FOR MYRTLE EXTRACT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(3), 804-817. SID. https://sid.ir/paper/288770/en

    Vancouver: Copy

    RAEISZADEH MAHBOOBEH, PARDAKHTY ABBAS, SHARIFIFAR FARIBA, MEHRABANI MEHRNAZ, NEJAT MEHRAB KERMANI HOJJAT, MEHRABANI MITRA. PHYTONIOSOME: A NOVEL DRUG DELIVERY FOR MYRTLE EXTRACT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(3):804-817. Available from: https://sid.ir/paper/288770/en

    IEEE: Copy

    MAHBOOBEH RAEISZADEH, ABBAS PARDAKHTY, FARIBA SHARIFIFAR, MEHRNAZ MEHRABANI, HOJJAT NEJAT MEHRAB KERMANI, and MITRA MEHRABANI, “PHYTONIOSOME: A NOVEL DRUG DELIVERY FOR MYRTLE EXTRACT,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 3, pp. 804–817, 2018, [Online]. Available: https://sid.ir/paper/288770/en

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