مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF ESBL, AMPC AND CARBAPENEMASE-PRODUCING ENTEROBACTERICEAE ISOLATED FROM HOSPITALIZED PATIENTS IN AZERBAIJAN, IRAN

Pages

  79-88

Abstract

 The current study was conducted to determine prevalence and antimicrobial susceptibility patterns, ESBL, AmpC and carbapenemase- producers among clinical isolates of Enterobacteriaceae. Three hundred and seven non-duplicative clinical isolates were collected from HOSPITALIZED PATIENTS in five medical centers in AZERBAIJAN, IRAN. Initial screening for β-lactamase production was performed using disc agar diffusion according to Clinical Laboratory Standards Institute (CLSI) guidelines. Phenotypic confirmatory tests was done using total ESBL/AmpC confirm kit, KPC/MBL and OXA-48 confirm kit according to manufacturer’s instructions. The overall prevalence of ESBL, AmpC, and carbapenemase-producing strains were 42.7% (131.307), 14.0% (43.307) and 4.9% (15.307), respectively. The prevalence of ESBLs was 38.35%, 64.9% and 35.7% for E. coli, K. pneumoniae and E. cloacae, respectively. Carbapenemase activity was only observed among 15 K. pneumoniae isolates and detected phenotypes include MBL (9.57, 15.8%), KPC (4.57, 7.0%), and OXA-48 (2.57, 3.5%). Fourteen out of 307 isolates (4.6%) were recognized to have ESBL or AmpC hyper-producer with decreased cell wall permeability phenotype. All 4 shigella strains were positive for ESBL and 4 isolates of P. mirabilis, 2 isolates of M. morganii and 1 seratia spp. were detected as AmpC producer. The only C. freundii strain isolated was positive for both ESBL and AmpC. This study reveals high prevalence of multidrug-resistant (MDR) b-lactamase-producing Enterobactericeae reaching 89.5%. Imipenem and meropenem showed potent antibacterial activities against all MDR b-lactamase-producers except for carbapenemase producers. After carbapenems, amikacin, piperacillin/tazobactam and amoxicillin/clavulanic acid were second the most effective drugs against b-lactamase-producing E. coli isolates.

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    APA: Copy

    GHOTASLOU, REZA, SADEGHI, MOHAMMAD REZA, AKHI, MOHAMMAD TAGHI, HASANI, ALKA, & ASGHARZADEH, MOHAMMAD. (2018). PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF ESBL, AMPC AND CARBAPENEMASE-PRODUCING ENTEROBACTERICEAE ISOLATED FROM HOSPITALIZED PATIENTS IN AZERBAIJAN, IRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(SUPPLEMENT), 79-88. SID. https://sid.ir/paper/288792/en

    Vancouver: Copy

    GHOTASLOU REZA, SADEGHI MOHAMMAD REZA, AKHI MOHAMMAD TAGHI, HASANI ALKA, ASGHARZADEH MOHAMMAD. PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF ESBL, AMPC AND CARBAPENEMASE-PRODUCING ENTEROBACTERICEAE ISOLATED FROM HOSPITALIZED PATIENTS IN AZERBAIJAN, IRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(SUPPLEMENT):79-88. Available from: https://sid.ir/paper/288792/en

    IEEE: Copy

    REZA GHOTASLOU, MOHAMMAD REZA SADEGHI, MOHAMMAD TAGHI AKHI, ALKA HASANI, and MOHAMMAD ASGHARZADEH, “PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF ESBL, AMPC AND CARBAPENEMASE-PRODUCING ENTEROBACTERICEAE ISOLATED FROM HOSPITALIZED PATIENTS IN AZERBAIJAN, IRAN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. SUPPLEMENT, pp. 79–88, 2018, [Online]. Available: https://sid.ir/paper/288792/en

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