مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

217
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

135
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

VALIDATED SPECTROPHTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF BUPRENORPHINE AND NALOXONE IN PHARMACEUTICAL DOSAGE FORMS

Pages

  112-119

Abstract

 Buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. A mixture of BUPRENORPHINE HYDROCHLORIDE and NALOXONE HYDROCHLORIDE has been approved for the treatment of opioid dependence.In this study a third order derivative spectrophotometric method based on zero- crossing technique has been used for the SIMULTANEOUS determination of BUPRENORPHINE HYDROCHLORIDE and NALOXONE HYDROCHLORIDE in tablets. The measurements were carried out at wavelengths of 257.8 (zero- crossing point of NALOXONE HYDROCHLORIDE) and 252.2 nm (zero-crossing point of buprenorphice hydrochloride) for BUPRENORPHINE HYDROCHLORIDE and NALOXONE HYDROCHLORIDE, respectively in the third order derivative spectra obtained in methanol and 0.1 M NaOH (50: 50) as solvent. The method was found to be linear in the range of 20-80 mg/mL for BUPRENORPHINE HYDROCHLORIDE and 5-20 mg/mL for NALOXONE HYDROCHLORIDE. The within-day and between- day coefficient of variation and error values were less than 2.5% and 1.8%, respectively. The proposed method was successfully used for SIMULTANEOUS determination of these drugs in pharmaceutical dosage form without any interference from excipients or need to prior separation before analysis.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SOURI, EFFAT, AHMADI, FARZANEH SADAT, BARAZANDEH TEHRANI, MALIHEH, MOHAMMADHOSSEINI, MAJID, & FADAYE VATAN, SEDIGHEH. (2017). VALIDATED SPECTROPHTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF BUPRENORPHINE AND NALOXONE IN PHARMACEUTICAL DOSAGE FORMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 112-119. SID. https://sid.ir/paper/288804/en

    Vancouver: Copy

    SOURI EFFAT, AHMADI FARZANEH SADAT, BARAZANDEH TEHRANI MALIHEH, MOHAMMADHOSSEINI MAJID, FADAYE VATAN SEDIGHEH. VALIDATED SPECTROPHTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF BUPRENORPHINE AND NALOXONE IN PHARMACEUTICAL DOSAGE FORMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):112-119. Available from: https://sid.ir/paper/288804/en

    IEEE: Copy

    EFFAT SOURI, FARZANEH SADAT AHMADI, MALIHEH BARAZANDEH TEHRANI, MAJID MOHAMMADHOSSEINI, and SEDIGHEH FADAYE VATAN, “VALIDATED SPECTROPHTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF BUPRENORPHINE AND NALOXONE IN PHARMACEUTICAL DOSAGE FORMS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 112–119, 2017, [Online]. Available: https://sid.ir/paper/288804/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button