SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4H-PYRANS AND SCHIFF BASES FUSED 4H-PYRAN DERIVATIVES AS INHIBITORS OF MYCOBACTERIUM BOVIS (BCG)

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Mahdavi Seyedeh Mahbobeh; HABIBI AZIZOLLAH; Dolati Hadi; SHAHCHERAGH SEYED MOHAMMAD; SARDARI SOROUSH; AZERANG PARISA

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Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:4 Page(s): 1229-1239

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Title

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4H-PYRANS AND SCHIFF BASES FUSED 4H-PYRAN DERIVATIVES AS INHIBITORS OF MYCOBACTERIUM BOVIS (BCG)

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Keywords

ANTIFUNGAL

ANTI-MYCOBACTERIUM

4H-PYRAN

N-METHYLMORPHOLINE

SCHIFF BASES

Abstract

The focus of our study is the synthesis and biological activity evaluation of a series of 4 H -Pyran compounds and SCHIFF BASES fused 4 H -Pyran derivatives which are known to possess a wide variety of biological activities. In this paper at first a simple and efficient one-pot synthesis of 4 H -Pyran s from the three-component reaction between malononitrile, aldehydes, and active methylene compounds in the presence of N -methylmorpholine (NMM) as catalyst at room temperature is reported, the reaction between these synthesized products and trimethylorthoformateor triethylorthoformateto produce schiff base compounds were also considered. The key advantages of synthesis of 4 H -Pyran derivatives are short reaction time, high yield, and simple work-up. Then, these compounds were evaluated for ANTI-MYCOBACTERIUM activity against Mycobacterium bovis (Bacillus Calmette–Guerin). The preliminary results indicated that most of the tested compounds showed relatively good activity against the test organism. Moreover, ANTIFUNGAL activities of these compounds were evaluated. Finally, their effect was more noticeable on Mycobacterium bovis (BCG).

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APA: Copy

Mahdavi, Seyedeh Mahbobeh, HABIBI, AZIZOLLAH, Dolati, Hadi, SHAHCHERAGH, SEYED MOHAMMAD, SARDARI, SOROUSH, & AZERANG, PARISA. (2018). SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4H-PYRANS AND SCHIFF BASES FUSED 4H-PYRAN DERIVATIVES AS INHIBITORS OF MYCOBACTERIUM BOVIS (BCG). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1229-1239. SID. https://sid.ir/paper/288883/en

Vancouver: Copy

Mahdavi Seyedeh Mahbobeh, HABIBI AZIZOLLAH, Dolati Hadi, SHAHCHERAGH SEYED MOHAMMAD, SARDARI SOROUSH, AZERANG PARISA. SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4H-PYRANS AND SCHIFF BASES FUSED 4H-PYRAN DERIVATIVES AS INHIBITORS OF MYCOBACTERIUM BOVIS (BCG). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1229-1239. Available from: https://sid.ir/paper/288883/en

IEEE: Copy

Seyedeh Mahbobeh Mahdavi, AZIZOLLAH HABIBI, Hadi Dolati, SEYED MOHAMMAD SHAHCHERAGH, SOROUSH SARDARI, and PARISA AZERANG, “SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4H-PYRANS AND SCHIFF BASES FUSED 4H-PYRAN DERIVATIVES AS INHIBITORS OF MYCOBACTERIUM BOVIS (BCG),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1229–1239, 2018, [Online]. Available: https://sid.ir/paper/288883/en

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