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Information Journal Paper

Title

FORMULATION OPTIMIZATION AND ASSESSMENT OF DEXAMETHASONE ORALLY DISINTEGRATING TABLETS USING BOX-BEHNKEN DESIGN

Pages

  1150-1163

Abstract

 The aim of this study was to prepare ORALLY DISINTEGRATING TABLETs (ODTs) containing DEXAMETHASONE (DEX) by direct compression method with sufficient hardness and rapid disintegration time. In order to save time, money, and human resources in designing and improvement of formulation, the statistical software Design Expert is used. Box–Behnken response surface methodology was applied to evaluate and optimize the effects of concentrations of three excipients, Kollidon CL-SF (X1), Pearlitol SD200 (X2), and Prosolv SMCC (X3) as independent factors on four responses: percentage of drug released after 5 min, disintegrating time, hardness, and friability. Thirteen formulations offered by the Box–Behnken design were prepared by direct compression method and ultimate weight of 200 mg, while the amount of DEX was 4 mg. All formulations were characterized for parameters such as diameter, hardness, weight, thickness, friability, and disintegration time. Following the statistical results, the effects of independent variables on responses were evaluated and the optimum formulation regarding acceptable responses consisted of 15% Kollidon, 39.66% Pearlitol, and 7.5% Prosolv which showed 95.28% release of the drug after 5 min, disintegrating time of 30 sec, 6.1 kg hardness, and 0.12% of friability with an acceptable taste as the optimized formulation.

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    • Cite

    APA: Copy

    SOROUSH, HADIS, GHORBANI BIDKORBEH, FATEMEH, MORTAZAVI, SEYED ALIREZA, & Mehramizi, Ali. (2018). FORMULATION OPTIMIZATION AND ASSESSMENT OF DEXAMETHASONE ORALLY DISINTEGRATING TABLETS USING BOX-BEHNKEN DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1150-1163. SID. https://sid.ir/paper/288909/en

    Vancouver: Copy

    SOROUSH HADIS, GHORBANI BIDKORBEH FATEMEH, MORTAZAVI SEYED ALIREZA, Mehramizi Ali. FORMULATION OPTIMIZATION AND ASSESSMENT OF DEXAMETHASONE ORALLY DISINTEGRATING TABLETS USING BOX-BEHNKEN DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1150-1163. Available from: https://sid.ir/paper/288909/en

    IEEE: Copy

    HADIS SOROUSH, FATEMEH GHORBANI BIDKORBEH, SEYED ALIREZA MORTAZAVI, and Ali Mehramizi, “FORMULATION OPTIMIZATION AND ASSESSMENT OF DEXAMETHASONE ORALLY DISINTEGRATING TABLETS USING BOX-BEHNKEN DESIGN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1150–1163, 2018, [Online]. Available: https://sid.ir/paper/288909/en

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