مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

211
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

110
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

PHYTOCHEMICAL ANALYSIS AND CENTRAL EFFECTS OF ANNONA MURICATA LINNAEUS: POSSIBLE INVOLVEMENT OF THE GABAERGIC AND MONOAMINERGIC SYSTEMS

Author(s)

 SOUZA DANIELE OLIVEIRA | SANTOS SALES VALTERLUCIO DOS | DE SOUZA RODRIGUES CRISTINA KELLY | DE OLIVEIRA LARISSA ROLIM | SANTIAGO LEMOS IZABEL CRISTINA | DELMONDES GYLLYANDESON DE ARAUJO | MONTEIRO ALEFE BRITO | DO NASCIMENTO EMMILY PETICIA | DE FIGUEIREDO FRANCISCO RODOLPHO SOBREIRA DANTAS NOBREGA | MARTINS DA COSTA JOSE GALBERTO | PINTO DA CRUZ GIOVANY MICHELY | DE BARROS VIANA GLAUCE SOCORRO | BARBOSA ROSELI | ALENCAR DE MENEZES IRWIN ROSE | BEZERRA FELIPE CICERO FRANCISCO | KERNTOPF MARTA REGINA | Issue Writer Certificate 

Pages

  1306-1317

Abstract

 ANNONA MURICATA Linnaeus (Annonaceae), popularly known as graviola, is used in folk medicine as both SEDATIVE and ANTICONVULSANT. This study correlates the neurochemical profile with the behavioral effects of the hydroalcoholic extract from the leaves of ANNONA MURICATA (HLEAM) in mice, proposing to elucidate their mechanism of action on the central nervous system. Flavonoids and PHENOLIC COMPOUNDS were identified and quantified by High Performance Liquid Chromatography (HPLC) method. The acute toxicity (median lethal dose - LD50) was determined by probitos method using the percentage of mortality based on the Hippocratic screen. HLEAM (25, 50 and 100 mg/kg) was tested, intraperitoneally (i.p.), in models of sedation, anxiety, motor coordination, and seizures. The endogenous levels of dopamine, norepinephrine and DOPAC were assayed by reverse-phase HPLC with electrochemical detection. The HPLC analysis of the extract revealed the presence of flavonoids (quercetin, isoquercitrin, quercitrin, rutin, and kaempferol) and phenolics acids (gallic, chlorogenic, ellagic and caffeic acids). The LD50 was 1091.7 mg/kg and Hippocratic screening indicated central nervous system depressant effect. HLEAM presented SEDATIVE effects at doses of 25, 50, and 100 mg/kg, as well as ANXIOLYTIC and ANTICONVULSANT effects at a dose of 100 mg/kg. In addition, these effects were partially reversed by flumazenil. The monoamines analysis by HPLC showed that HLEAM decreased the level of norepinefrine and dopamine in the mouse brain striatum. Thus, the results indicate a possible interaction of HLEAM with the GABAergic and MONOAMINERGIC SYSTEMs, adding medicinal value to the popular use of the plant for the treatment of behavioral and neurological disorders.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SOUZA, DANIELE OLIVEIRA, SANTOS SALES, VALTERLUCIO DOS, DE SOUZA RODRIGUES, CRISTINA KELLY, DE OLIVEIRA, LARISSA ROLIM, SANTIAGO LEMOS, IZABEL CRISTINA, DELMONDES, GYLLYANDESON DE ARAUJO, MONTEIRO, ALEFE BRITO, DO NASCIMENTO, EMMILY PETICIA, DE FIGUEIREDO, FRANCISCO RODOLPHO SOBREIRA DANTAS NOBREGA, MARTINS DA COSTA, JOSE GALBERTO, PINTO DA CRUZ, GIOVANY MICHELY, DE BARROS VIANA, GLAUCE SOCORRO, BARBOSA, ROSELI, ALENCAR DE MENEZES, IRWIN ROSE, BEZERRA FELIPE, CICERO FRANCISCO, & KERNTOPF, MARTA REGINA. (2018). PHYTOCHEMICAL ANALYSIS AND CENTRAL EFFECTS OF ANNONA MURICATA LINNAEUS: POSSIBLE INVOLVEMENT OF THE GABAERGIC AND MONOAMINERGIC SYSTEMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1306-1317. SID. https://sid.ir/paper/288917/en

    Vancouver: Copy

    SOUZA DANIELE OLIVEIRA, SANTOS SALES VALTERLUCIO DOS, DE SOUZA RODRIGUES CRISTINA KELLY, DE OLIVEIRA LARISSA ROLIM, SANTIAGO LEMOS IZABEL CRISTINA, DELMONDES GYLLYANDESON DE ARAUJO, MONTEIRO ALEFE BRITO, DO NASCIMENTO EMMILY PETICIA, DE FIGUEIREDO FRANCISCO RODOLPHO SOBREIRA DANTAS NOBREGA, MARTINS DA COSTA JOSE GALBERTO, PINTO DA CRUZ GIOVANY MICHELY, DE BARROS VIANA GLAUCE SOCORRO, BARBOSA ROSELI, ALENCAR DE MENEZES IRWIN ROSE, BEZERRA FELIPE CICERO FRANCISCO, KERNTOPF MARTA REGINA. PHYTOCHEMICAL ANALYSIS AND CENTRAL EFFECTS OF ANNONA MURICATA LINNAEUS: POSSIBLE INVOLVEMENT OF THE GABAERGIC AND MONOAMINERGIC SYSTEMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1306-1317. Available from: https://sid.ir/paper/288917/en

    IEEE: Copy

    DANIELE OLIVEIRA SOUZA, VALTERLUCIO DOS SANTOS SALES, CRISTINA KELLY DE SOUZA RODRIGUES, LARISSA ROLIM DE OLIVEIRA, IZABEL CRISTINA SANTIAGO LEMOS, GYLLYANDESON DE ARAUJO DELMONDES, ALEFE BRITO MONTEIRO, EMMILY PETICIA DO NASCIMENTO, FRANCISCO RODOLPHO SOBREIRA DANTAS NOBREGA DE FIGUEIREDO, JOSE GALBERTO MARTINS DA COSTA, GIOVANY MICHELY PINTO DA CRUZ, GLAUCE SOCORRO DE BARROS VIANA, ROSELI BARBOSA, IRWIN ROSE ALENCAR DE MENEZES, CICERO FRANCISCO BEZERRA FELIPE, and MARTA REGINA KERNTOPF, “PHYTOCHEMICAL ANALYSIS AND CENTRAL EFFECTS OF ANNONA MURICATA LINNAEUS: POSSIBLE INVOLVEMENT OF THE GABAERGIC AND MONOAMINERGIC SYSTEMS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1306–1317, 2018, [Online]. Available: https://sid.ir/paper/288917/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button