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Information Journal Paper

Title

SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF SPIRO-4H-PYRANDERIVATIVES ON SOME GRAM POSITIVE AND GRAM NEGATIVE BACTERIA

Pages

  943-952

Abstract

 Infections are one of the most important causes of death, disability and inappropriateconditions for millions of people around the world. Therefore, the development in prognosis, prevention and treatment of infectious diseases made a considerable progress in designing andsynthesis of new antimicrobial drugs. Nowadays, due to the increase in microbial resistance, discovery of new compounds with broad spectrum effects is granted. 4H-pyran derivatives andspiro compounds are the most important fragments in some effective drugs with antimicrobialactivity. Therefore, in this study, 6 compounds with SPIRO-4H-PYRAN core were synthesizedand evaluated for their antimicrobial activity against four different bacterial species usingMICROBROTH DILUTION and DISK DIFFUSION methods. Minimum inhibitory concentration (MIC) hasbeen measured for each compound and also for the standard antibiotic, gentamicin, and theywere all compared together. According to our result, one of the spiropyran derivative (5d)containing both the indole and the cytosine ring, has been shown good antibacterial effectsagainst standard and clinical isolates of Staphylococcus aureus and STREPTOCOCCUS PYOGENES.

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    APA: Copy

    NAZARI, PARDIS, BAZI, ALIYEH, Ayatollahi, Seyed Abdulmajid, Dolati, Hadi, Mahdavi, Seyedeh Mahbobeh, RAFIGHDOOST, LALEH, & AMIRMOSTOFIAN, MARZIEH. (2017). SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF SPIRO-4H-PYRANDERIVATIVES ON SOME GRAM POSITIVE AND GRAM NEGATIVE BACTERIA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 943-952. SID. https://sid.ir/paper/288967/en

    Vancouver: Copy

    NAZARI PARDIS, BAZI ALIYEH, Ayatollahi Seyed Abdulmajid, Dolati Hadi, Mahdavi Seyedeh Mahbobeh, RAFIGHDOOST LALEH, AMIRMOSTOFIAN MARZIEH. SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF SPIRO-4H-PYRANDERIVATIVES ON SOME GRAM POSITIVE AND GRAM NEGATIVE BACTERIA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):943-952. Available from: https://sid.ir/paper/288967/en

    IEEE: Copy

    PARDIS NAZARI, ALIYEH BAZI, Seyed Abdulmajid Ayatollahi, Hadi Dolati, Seyedeh Mahbobeh Mahdavi, LALEH RAFIGHDOOST, and MARZIEH AMIRMOSTOFIAN, “SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF SPIRO-4H-PYRANDERIVATIVES ON SOME GRAM POSITIVE AND GRAM NEGATIVE BACTERIA,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 943–952, 2017, [Online]. Available: https://sid.ir/paper/288967/en

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