EVALUATION OF A 99MTC-TRICINE VASCULAR DISRUPTING AGENT AS AN IN-VIVOIMAGING IN 4T1 MOUSE BREAST TUMOR MODEL

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ERFANI MOSTAFA; SHIRMARDI SEYED PEZHMAN; SHAFIEI MOHAMMAD

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Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 999-1006

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Title

EVALUATION OF A 99MTC-TRICINE VASCULAR DISRUPTING AGENT AS AN IN-VIVOIMAGING IN 4T1 MOUSE BREAST TUMOR MODEL

Author(s)

ERFANI MOSTAFA | SHIRMARDI SEYED PEZHMAN | SHAFIEI MOHAMMAD | Issue Writer Certificate

Keywords

DEACETYLCOLCHICINE;LABELING;PHARMACOKINETICS;TRICINE;4T1 TUMOR

Abstract

Colchicine as a vascular disrupting agent creates microtubule destabilization whichinduces vessel blockage and consequently cell death. Accordingly, colchicines and itsanalogues radiolabeled with 99mTc may have potential for visualization of tumor. In this work, deacetylcolchicine a colchicine analogue was labeled with 99mTc via tricine as a coligandand characterized for its tumor targeting properties. The in-vitro radiochemical stability andthe biodistribution were studied in 4T1 breast tumor model bearing mice. Labeling yield ofmore than 90% was obtained corresponding to a specific activity of 46 MBq/μ mol. In-vivobiodistribution studies demonstrated that radiocomplex had high tumor to muscle and tumor toblood ratios at early time points. Planer gamma imaging of tumor bearing mice showed that thisradioconjugate was able to clearly visualize tumors. According to high tumor uptake, presentedradiocomplex may have a potential for targeted imaging studies.

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APA: Copy

ERFANI, MOSTAFA, SHIRMARDI, SEYED PEZHMAN, & SHAFIEI, MOHAMMAD. (2017). EVALUATION OF A 99MTC-TRICINE VASCULAR DISRUPTING AGENT AS AN IN-VIVOIMAGING IN 4T1 MOUSE BREAST TUMOR MODEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 999-1006. SID. https://sid.ir/paper/288968/en

Vancouver: Copy

ERFANI MOSTAFA, SHIRMARDI SEYED PEZHMAN, SHAFIEI MOHAMMAD. EVALUATION OF A 99MTC-TRICINE VASCULAR DISRUPTING AGENT AS AN IN-VIVOIMAGING IN 4T1 MOUSE BREAST TUMOR MODEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):999-1006. Available from: https://sid.ir/paper/288968/en

IEEE: Copy

MOSTAFA ERFANI, SEYED PEZHMAN SHIRMARDI, and MOHAMMAD SHAFIEI, “EVALUATION OF A 99MTC-TRICINE VASCULAR DISRUPTING AGENT AS AN IN-VIVOIMAGING IN 4T1 MOUSE BREAST TUMOR MODEL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 999–1006, 2017, [Online]. Available: https://sid.ir/paper/288968/en

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