SELECTIVE ACTIVITY OF OLEANOLIC AND MASLINIC ACIDS ON THE AMASTIGOTE FORM OF LEISHMANIA SPP

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SIFAOUI INES; LOPEZ ARENCIBIA ATTENERI; MARTIN NAVARRO CARMEN M.; REYES BATLLE MARIA; MEJRI MONDHER; VALLADARES BASILIO; LORENZO MORALES JACOB; ABDERABBA MANEF; PINERO JOSE ENRIQUE

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1190-1193

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Title

SELECTIVE ACTIVITY OF OLEANOLIC AND MASLINIC ACIDS ON THE AMASTIGOTE FORM OF LEISHMANIA SPP

Author(s)

Keywords

OLEANOLIC ACID

MASLINIC ACID

TRITERPENIC ACIDS

ANTI-AMASTIGOTES ACTIVITY

SELECTIVITY INDEX

Abstract

Leishmaniasis represents a serious threat to the health as one of the most important neglectedtropical diseases as designated by the World Health Organization. The disease is endemic in82 countries, among them Tunisia is an indigenous area for cutaneous Leishmaniasis. In aprevious work, two tritepenic acids namely oleanolic and MASLINIC ACIDs have been isolatedfrom olive leaf extract. In the present paper, the in vitro activity against amastigotes stage ofLeishmania (L. ) infantum and Leishmania (L. ) amazonensis was investigated. MASLINIC ACIDshowed the highest activity, against L. amazonensis, with an IC50 of 1. 417 ± 0. 401 μ g/mL anda SELECTIVITY INDEX of 9. 405. Although, the OLEANOLIC ACID exhibit a better activity against L. infantum with an IC50 of 0. 999 ± 0. 089 μ g/mL and SELECTIVITY INDEX of 8. 111.

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APA: Copy

SIFAOUI, INES, LOPEZ ARENCIBIA, ATTENERI, MARTIN NAVARRO, CARMEN M., REYES BATLLE, MARIA, MEJRI, MONDHER, VALLADARES, BASILIO, LORENZO MORALES, JACOB, ABDERABBA, MANEF, & PINERO, JOSE ENRIQUE. (2017). SELECTIVE ACTIVITY OF OLEANOLIC AND MASLINIC ACIDS ON THE AMASTIGOTE FORM OF LEISHMANIA SPP. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1190-1193. SID. https://sid.ir/paper/288972/en

Vancouver: Copy

SIFAOUI INES, LOPEZ ARENCIBIA ATTENERI, MARTIN NAVARRO CARMEN M., REYES BATLLE MARIA, MEJRI MONDHER, VALLADARES BASILIO, LORENZO MORALES JACOB, ABDERABBA MANEF, PINERO JOSE ENRIQUE. SELECTIVE ACTIVITY OF OLEANOLIC AND MASLINIC ACIDS ON THE AMASTIGOTE FORM OF LEISHMANIA SPP. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1190-1193. Available from: https://sid.ir/paper/288972/en

IEEE: Copy

INES SIFAOUI, ATTENERI LOPEZ ARENCIBIA, CARMEN M. MARTIN NAVARRO, MARIA REYES BATLLE, MONDHER MEJRI, BASILIO VALLADARES, JACOB LORENZO MORALES, MANEF ABDERABBA, and JOSE ENRIQUE PINERO, “SELECTIVE ACTIVITY OF OLEANOLIC AND MASLINIC ACIDS ON THE AMASTIGOTE FORM OF LEISHMANIA SPP,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1190–1193, 2017, [Online]. Available: https://sid.ir/paper/288972/en

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