مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

201
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

110
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

COMPARISON OF KINETIC STUDY AND PROTECTIVE EFFECTS OF BIOLOGICALDIPEPTIDE AND TWO PORPHYRIN DERIVATIVES ON METAL CYTOTOXICITY TOWARDHUMAN LYMPHOCYTES

Pages

  1059-1070

Abstract

 In this research, DIPEPTIDE (his-β-alanine) and PORPHYRIN derivatives were choosen forcomparing chelating ability of TOXIC METALS such as Al3+, Cu2+, Hg2+ and Pb2+ in-vitro. The reasonfor choosing these two compounds is that both of them are naturally present in biologicalsystems and comparison of chelating ability of these two compounds has not yet been done. Synthesis and comparison of kinetic study of DIPEPTIDE (his-β-alanine), meso-tetrakis(4-trimethylanilinium) PORPHYRIN (TAPP) and Tetrakis(4-sulfonatophenyl)PORPHYRIN (TPPS4)were carried out by our team. In addition, CYTOTOXICITY assays of metals and CHELATORs werealso performed using methylthiazoletetrazolium (MTT) test. Furthermore we investigated theprotective effect of CHELATORs against CYTOTOXICITY, induced by differenrt TOXIC METALS such asAl3+, Cu2+, Hg2+ and Pb2+ on human LYMPHOCYTES. EC50 values on human LYMPHOCYTES obtainedafter 12 h. incubation for Al3+, Cu2+ and Hg2+ were 30, 51, 3 μ M respectively and for Pb2+ noCYTOTOXICITY was observed on human lymphocyte up to 1000 μ M concentration. EC50 obtainedfor CHELATORs DIPEPTIDE, TPPS4 and TAPP were 948, 472 and 175 μ M respectively. Pretreatmentof human lymphocyte with subtoxic concentations of CHELATORs reduced toxicity of the metalsagainst human blood LYMPHOCYTES.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    KHOSRAVI, MARYAM, RAHIMI, RAHMATOLLAH, POURAHMAD, JALAL, Zarei, Mohammad Hadi, & RABBANI, MAHBOUBEH. (2017). COMPARISON OF KINETIC STUDY AND PROTECTIVE EFFECTS OF BIOLOGICALDIPEPTIDE AND TWO PORPHYRIN DERIVATIVES ON METAL CYTOTOXICITY TOWARDHUMAN LYMPHOCYTES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1059-1070. SID. https://sid.ir/paper/288989/en

    Vancouver: Copy

    KHOSRAVI MARYAM, RAHIMI RAHMATOLLAH, POURAHMAD JALAL, Zarei Mohammad Hadi, RABBANI MAHBOUBEH. COMPARISON OF KINETIC STUDY AND PROTECTIVE EFFECTS OF BIOLOGICALDIPEPTIDE AND TWO PORPHYRIN DERIVATIVES ON METAL CYTOTOXICITY TOWARDHUMAN LYMPHOCYTES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1059-1070. Available from: https://sid.ir/paper/288989/en

    IEEE: Copy

    MARYAM KHOSRAVI, RAHMATOLLAH RAHIMI, JALAL POURAHMAD, Mohammad Hadi Zarei, and MAHBOUBEH RABBANI, “COMPARISON OF KINETIC STUDY AND PROTECTIVE EFFECTS OF BIOLOGICALDIPEPTIDE AND TWO PORPHYRIN DERIVATIVES ON METAL CYTOTOXICITY TOWARDHUMAN LYMPHOCYTES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1059–1070, 2017, [Online]. Available: https://sid.ir/paper/288989/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button