ONCE VERSUS THRICE DAILY COLISTIN IN CRITICALLY ILL PTIENTS WITH MULTI-DRUG RESISTANT INFECTIONS

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GHAZAEIAN MONIREH; MOKHTARI MAJID; KOUCHEK MEHRAN; MIRI MIR MOHAMMAD; GOHARANI REZA; GHODSSI GHASSEMABADI ROBABEH; SISTANIZAD MOHAMMAD

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1247-1253

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Title

ONCE VERSUS THRICE DAILY COLISTIN IN CRITICALLY ILL PTIENTS WITH MULTI-DRUG RESISTANT INFECTIONS

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Keywords

PROCALCITONIN

COLISTIN

CRITICALLY ILL PATIENTS

DOSING INTERVAL

MDR INFECTIONS

Abstract

The aim of this study was to evaluate the PROCALCITONIN (PCT) changes in two different highdoseCOLISTIN regimens in the treatment of multi-drug resistant MDR gram negative infectionsin ICU patients. This is a prospective study of adult ICU patients with bacteremia and ventilator associatedpneumonia (VAP) caused by MDR gram negative pathogens. Patients were assigned to twoCOLISTIN administration groups. Group A received 9 and group B received 3 million internationalunits every 24 and 8 h respectively. Baseline characteristics and measurements of PCTconcentrations at the start, the 3rd and the 5th day of the antibiotic therapy and their trendsbetween the two groups were recorded and compared. of 40 patients enrolled, 34 completed the study protocol, of whom 30 (88. 2%) had (VAP)and 4 (11. 8%) had bacteremia. There were no statistically significant differences in the baselinecharacteristics between the two groups. The mean PCT levels in two study groups were; 2. 34, 1. 24, and 0. 95 in group A and 5. 89, 1. 24 and 0. 8 in group B at the baseline, 3rd and 5th day ofCOLISTIN administration respectively (P=0. 47). The ICU length of stay (LOS) in days and ICUmortality were; 31. 31, 35. 3% and 32. 06, 22. 2% in groups A and B (P=0. 39, 0. 87), respectively. Conclusion: We did not find any statistically significant differences in the serum PCT levels, ICU LOS or ICU mortality, between the two groups, who received maximum recommendeddose of CMS with 2 different intervals of every 8 or 24 h.

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APA: Copy

GHAZAEIAN, MONIREH, MOKHTARI, MAJID, KOUCHEK, MEHRAN, MIRI, MIR MOHAMMAD, GOHARANI, REZA, GHODSSI GHASSEMABADI, ROBABEH, & SISTANIZAD, MOHAMMAD. (2017). ONCE VERSUS THRICE DAILY COLISTIN IN CRITICALLY ILL PTIENTS WITH MULTI-DRUG RESISTANT INFECTIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1247-1253. SID. https://sid.ir/paper/288993/en

Vancouver: Copy

GHAZAEIAN MONIREH, MOKHTARI MAJID, KOUCHEK MEHRAN, MIRI MIR MOHAMMAD, GOHARANI REZA, GHODSSI GHASSEMABADI ROBABEH, SISTANIZAD MOHAMMAD. ONCE VERSUS THRICE DAILY COLISTIN IN CRITICALLY ILL PTIENTS WITH MULTI-DRUG RESISTANT INFECTIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1247-1253. Available from: https://sid.ir/paper/288993/en

IEEE: Copy

MONIREH GHAZAEIAN, MAJID MOKHTARI, MEHRAN KOUCHEK, MIR MOHAMMAD MIRI, REZA GOHARANI, ROBABEH GHODSSI GHASSEMABADI, and MOHAMMAD SISTANIZAD, “ONCE VERSUS THRICE DAILY COLISTIN IN CRITICALLY ILL PTIENTS WITH MULTI-DRUG RESISTANT INFECTIONS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1247–1253, 2017, [Online]. Available: https://sid.ir/paper/288993/en

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