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Information Journal Paper

Title

SYNTHESIS AND BIOLOGICAL EVALUATION OF THIOSEMICARBAZIDE DERIVATIVES ENDOWED WITH HIGH ACTIVITY TOWARD MYCOBACTERIUM BOVIS

Pages

  1128-1140

Abstract

 Thiosemicarbazides are potent intermediates for the synthesis of pharmaceutical andbioactive materials and thus, they are used extensively in the field of MEDICINAL CHEMISTRY. Theimine bond (-N=CH-) in this compounds are useful in organic synthesis, in particular for thepreparation of heterocycles and non-natural β-aminoacids. In this paper the synthesis of somenew THIOSEMICARBAZIDE DERIVATIVES by condensation reaction of various aldehydes or ketoneswith 4-phenylthiosemicarbazide or thiosemicarbazide is reported. This synthesis method hasthe advantages of high yields and good bioactivity. The structures of these compounds wereconfi rmed by IR, mass, 1H NMR, 13C NMR, and single-crystal X-ray diffraction studies. Allof these compounds were tested for their in-vitro anti-mycobacterial activity. The influenceof the functional group and position of substituent on anti-bacterial activity of compounds isinvestigated too. The preliminary results indicated that all of the tested compounds showedgood activity against the test organism. The compounds 11 and 30 showed the highest antitubercularactivity (0. 39 μ g/mL). This synthesis method has the advantages of high yields andgood bioactivity.

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    APA: Copy

    SARDARI, SOROUSH, FEYZI, SAMANEH, REZAYAN, ALI HOSSEIN, AZERANG, PARISA, SHAHCHERAGH, SEYED MOHAMMAD, GHAVAMI, GHAZALEH, & HABIBI, AZIZOLLAH. (2017). SYNTHESIS AND BIOLOGICAL EVALUATION OF THIOSEMICARBAZIDE DERIVATIVES ENDOWED WITH HIGH ACTIVITY TOWARD MYCOBACTERIUM BOVIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1128-1140. SID. https://sid.ir/paper/288997/en

    Vancouver: Copy

    SARDARI SOROUSH, FEYZI SAMANEH, REZAYAN ALI HOSSEIN, AZERANG PARISA, SHAHCHERAGH SEYED MOHAMMAD, GHAVAMI GHAZALEH, HABIBI AZIZOLLAH. SYNTHESIS AND BIOLOGICAL EVALUATION OF THIOSEMICARBAZIDE DERIVATIVES ENDOWED WITH HIGH ACTIVITY TOWARD MYCOBACTERIUM BOVIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1128-1140. Available from: https://sid.ir/paper/288997/en

    IEEE: Copy

    SOROUSH SARDARI, SAMANEH FEYZI, ALI HOSSEIN REZAYAN, PARISA AZERANG, SEYED MOHAMMAD SHAHCHERAGH, GHAZALEH GHAVAMI, and AZIZOLLAH HABIBI, “SYNTHESIS AND BIOLOGICAL EVALUATION OF THIOSEMICARBAZIDE DERIVATIVES ENDOWED WITH HIGH ACTIVITY TOWARD MYCOBACTERIUM BOVIS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1128–1140, 2017, [Online]. Available: https://sid.ir/paper/288997/en

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