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Information Journal Paper

Title

MICROBIAL HYDROXYLATION OF 16α , 17α-EPOXYPROGESTERONE BY PENICILLIUMDECUMBENS

Pages

  1161-1166

Abstract

 Microbial transformation has been successfully applied in the production of STEROIDintermediates with therapeutic use and commercial value in pharmaceutical industry due to itshigh regio-and stereo-selectivity. As such, it is still important to screen microbial strains withnovel activity or more efficient abilities in the development of the commercial STEROID industry. BIOTRANSFORMATION of STEROID: 16α; , 17α;-EPOXYPROGESTERONE (1). using Penicilliumdecumbens asbiocatalyst was investigated and selective HYDROXYLATION of 1 was observed. The products wereseparated by silica gel column chromatography, and the structure determination was performedby MS, NMR, and X-ray crystallography. BIOTRANSFORMATION of 1 afforded 7β-hydroxy-16α; , 17α;-EPOXYPROGESTERONE (2). and 7β , 11α-dihydroxy-16α; , 17α;-EPOXYPROGESTERONE (3). The twonovel metabolic products 2 and 3 were reported for the first time. Moreover, the identifiedC7β-and C11-α HYDROXYLATION is a novel reaction of microbial transformation of STEROIDs byP. decumbens.

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    • Cite

    APA: Copy

    MAO, SHUHONG, WANG, XUERONG, GE, ZHIJIANG, SU, AN, ZHANG, LIXIA, LI, YANQING, LIU, XIAOGUANG, & LU, FUPING. (2017). MICROBIAL HYDROXYLATION OF 16α , 17α-EPOXYPROGESTERONE BY PENICILLIUMDECUMBENS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1161-1166. SID. https://sid.ir/paper/288998/en

    Vancouver: Copy

    MAO SHUHONG, WANG XUERONG, GE ZHIJIANG, SU AN, ZHANG LIXIA, LI YANQING, LIU XIAOGUANG, LU FUPING. MICROBIAL HYDROXYLATION OF 16α , 17α-EPOXYPROGESTERONE BY PENICILLIUMDECUMBENS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1161-1166. Available from: https://sid.ir/paper/288998/en

    IEEE: Copy

    SHUHONG MAO, XUERONG WANG, ZHIJIANG GE, AN SU, LIXIA ZHANG, YANQING LI, XIAOGUANG LIU, and FUPING LU, “MICROBIAL HYDROXYLATION OF 16α , 17α-EPOXYPROGESTERONE BY PENICILLIUMDECUMBENS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1161–1166, 2017, [Online]. Available: https://sid.ir/paper/288998/en

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