SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY STUDIES ONFANLIZHICYCLOPEPTIDE A

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DAHIYA RAJIV; SINGH SUNIL

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1176-1184

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Information Journal Paper

Title

SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY STUDIES ONFANLIZHICYCLOPEPTIDE A

Author(s)

DAHIYA RAJIV | SINGH SUNIL | Issue Writer Certificate

Keywords

FANLIZHICYCLOPEPTIDE A;CYCLIC HEPTAPEPTIDE;SOLUTION

PHASE SYNTHESIS;MACROCYCLIZATION;PHARMACOLOGICAL ACTIVITY

Abstract

The synthesis of a proline-rich cyclic heptapeptide, fanlizhicyclopeptide A (8), previouslyisolated from the fruits of Annona squamosa (sugar-apples), is described via coupling oftetrapeptide l-prolyl-l-tyrosyl-l-leucyl-l-proline methyl ester with tripeptide Boc-glycyl-lvalyl-l-proline followed by cyclization of the linear fragment having seven amino acid units. Structure of the synthesized cyclooligopeptide was confirmed by the means of chemical andspectroscopic methods including FTIR, 1H NMR, 13C NMR, FABMS and further, subjected tothe anthelmintic, antibacterial and the antifungal activity studies. Bioactivity results indicatedthat the newly synthesized cyclic peptide displayed potent anthelmintic activity against the threeearthworm species Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus eugeniaeat 2 mg/mL and remarkable anti-dermatophytic activities against Trichophyton mentagrophytesand Microsporum audouinii at concentration of 6 μ g/mL.

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APA: Copy

DAHIYA, RAJIV, & SINGH, SUNIL. (2017). SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY STUDIES ONFANLIZHICYCLOPEPTIDE A. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1176-1184. SID. https://sid.ir/paper/289001/en

Vancouver: Copy

DAHIYA RAJIV, SINGH SUNIL. SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY STUDIES ONFANLIZHICYCLOPEPTIDE A. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1176-1184. Available from: https://sid.ir/paper/289001/en

IEEE: Copy

RAJIV DAHIYA, and SUNIL SINGH, “SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY STUDIES ONFANLIZHICYCLOPEPTIDE A,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1176–1184, 2017, [Online]. Available: https://sid.ir/paper/289001/en

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