Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies

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Eroglu Barbaros; Ozadali Sari Keriman; Unsal Tan Oya; Dharmarajan Sriram; Yogeeswari Perumal; Balkan Ayla

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:4 Page(s): 783-790

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Information Journal Paper

Title

Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies

Author(s)

Keywords

Thiazolidin-4-one;

Triazole;

Imidazole;

Antimycobacterial activity

Abstract

To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenagel condensation. To evaluate their structures 1H NMR, IR, mass spectrometry and elemental analysis data were used. The target compounds were screened for their Antimycobacterial activity against M. tuberculosis H37Rv strain using the microplate alamar blue assay method. Among them, 6, 10 and 12 (MIC: 14. 27-14. 74 μ M) were found as most active compounds in the series. It was seen that both phenylamino and benzylidene substitutions on thiazolidin-4-one ring caused an improvement in the Antimycobacterial activity.

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APA: Copy

Eroglu, Barbaros, Ozadali Sari, Keriman, Unsal Tan, Oya, Dharmarajan, Sriram, Yogeeswari, Perumal, & Balkan, Ayla. (2016). Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(4), 783-790. SID. https://sid.ir/paper/289049/en

Vancouver: Copy

Eroglu Barbaros, Ozadali Sari Keriman, Unsal Tan Oya, Dharmarajan Sriram, Yogeeswari Perumal, Balkan Ayla. Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(4):783-790. Available from: https://sid.ir/paper/289049/en

IEEE: Copy

Barbaros Eroglu, Keriman Ozadali Sari, Oya Unsal Tan, Sriram Dharmarajan, Perumal Yogeeswari, and Ayla Balkan, “Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 4, pp. 783–790, 2016, [Online]. Available: https://sid.ir/paper/289049/en

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