Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

202
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

125
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Effects of Phenylglyoxal and N-ethylmaleimide Concentration on Mycophenolic Acid Production by Penicillium brevi-compactum ATCC16024

Pages

  925-931

Abstract

 Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fermentation was performed in 250 mL shake flasks at 24 ° C and 200 rpm in a rotary shaker for 300 h using a basic culture medium containing different concentrations of phenylglyoxal and n-ethylmaleimide ranged from 0 to 20 mg. L-1. For the basic medium without any amounts of phenylglyoxal and n-ethylmaleimide (control), maximum MPA production, product yield and productivity of process was in order, 1. 5042 g. L-1, 20. 3 mg. g-1 consumed glucose and 5. 37 mg. L-1h-1. Maximum produced MPA of 2. 9032 g. L-1, MPA yield of 39. 23 mg. g-1 of consumed glucose, productivity of 10. 37 mg. L-1 h-1 and total enhancement of 93. 11% was obtained when the culture medium was contained 18 mg. L-1 of phenylglyoxal, represented more than 93% raising in compare to control. Maximum MPA concentration, yield and productivity in order was obtained 3. 1123 g. L-1, 42. 06 mg. g-1 of consumed glucose and 11. 11 mg. L-1 h-1, with using 6 mg. L-1 of n-ethylmaleimide. N-ethylmaleimide was caused to 2. 138 folds (106. 89%) increase in MPA production by P. brevi-compactum ATCC16024.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    ARDESTANI, FATEMEH. (2016). Effects of Phenylglyoxal and N-ethylmaleimide Concentration on Mycophenolic Acid Production by Penicillium brevi-compactum ATCC16024. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(4), 925-931. SID. https://sid.ir/paper/289059/en

    Vancouver: Copy

    ARDESTANI FATEMEH. Effects of Phenylglyoxal and N-ethylmaleimide Concentration on Mycophenolic Acid Production by Penicillium brevi-compactum ATCC16024. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(4):925-931. Available from: https://sid.ir/paper/289059/en

    IEEE: Copy

    FATEMEH ARDESTANI, “Effects of Phenylglyoxal and N-ethylmaleimide Concentration on Mycophenolic Acid Production by Penicillium brevi-compactum ATCC16024,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 4, pp. 925–931, 2016, [Online]. Available: https://sid.ir/paper/289059/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top