Randomized Trial of the Effect of Magnesium Sulfate Continuous Infusion on IL-6 and CRP Serum Levels Following Abdominal Aortic Aneurysm Surgery

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MOJTAHEDZADEH MOJTABA; chelkeba Legese; Ranjvar Shahrivar Mona; NAJAFI ATABAK; MOINI MAJID; NAJMEDDIN FARHAD; SADEGHI KOUROSH; BARKHORDARI KHOSRO; Gheymati Azin; AHMADI AREZOO

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:4 Page(s): 951-956

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Title

Randomized Trial of the Effect of Magnesium Sulfate Continuous Infusion on IL-6 and CRP Serum Levels Following Abdominal Aortic Aneurysm Surgery

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Keywords

Abdominal aortic aneurysm (AAA)

Magnesium Sulfate (MgSo4)

Interleukin 6 (IL-6)

C-reactive protein (CRP)

Abstract

Abdominal aortic aneurysm (AAA) is widely considered as the disease of elderly white men. Inflammation is one of the most well-known mechanisms involved in the pathogenesis of AAA. Magnesium is one of the most important minerals in the body with established antiinflammatory effects. In this study, we aimed to investigate the impact of Mg loading following AAA surgery on two inflammation markers, IL-6 and CRP, as well as patientʼ s outcome. This study was conducted as a randomized clinical trial on 18 patients (divided into two groups) after surgical correction of Acute Aortic Aneurysm (AAA). All the patients admitted in ICU ward of Sina Hospital. In intervention group, 10 g of MgSO4 has been infused through 12 h. The control group has not received the intervention. IL-6 and CRP were measured and compared at times 0, 12, 24 and 36 h. The patients were monitored for 36 h. After intervention, the differences of heart rate and APACHE II score were not statistically significant between intervention and control groups (P = 0. 097 and P = 0. 472, respectively). IL-6 levels decreased consistently in both groups after inclusion in the study. However, IL-6 level was significantly less in intervention group early after the end of MgSO4 infusion comparing with control group (P = 0. 01). Likewise, the CRP level decreased significantly after inclusion in the study (P = 0. 005). However, these changes were not significant between intervention and control groups (P = 0. 297). According to the results of this study, continuous infusion of MgSO4 after AAA surgery may provide IL-6 suppression.

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APA: Copy

chelkeba, Legese, Ranjvar Shahrivar, Mona, NAJAFI, ATABAK, MOINI, MAJID, NAJMEDDIN, FARHAD, SADEGHI, KOUROSH, BARKHORDARI, KHOSRO, Gheymati, Azin, & AHMADI, AREZOO. (2016). Randomized Trial of the Effect of Magnesium Sulfate Continuous Infusion on IL-6 and CRP Serum Levels Following Abdominal Aortic Aneurysm Surgery. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(4), 951-956. SID. https://sid.ir/paper/289061/en

Vancouver: Copy

chelkeba Legese, Ranjvar Shahrivar Mona, NAJAFI ATABAK, MOINI MAJID, NAJMEDDIN FARHAD, SADEGHI KOUROSH, BARKHORDARI KHOSRO, Gheymati Azin, AHMADI AREZOO. Randomized Trial of the Effect of Magnesium Sulfate Continuous Infusion on IL-6 and CRP Serum Levels Following Abdominal Aortic Aneurysm Surgery. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(4):951-956. Available from: https://sid.ir/paper/289061/en

IEEE: Copy

Legese chelkeba, Mona Ranjvar Shahrivar, ATABAK NAJAFI, MAJID MOINI, FARHAD NAJMEDDIN, KOUROSH SADEGHI, KHOSRO BARKHORDARI, Azin Gheymati, and AREZOO AHMADI, “Randomized Trial of the Effect of Magnesium Sulfate Continuous Infusion on IL-6 and CRP Serum Levels Following Abdominal Aortic Aneurysm Surgery,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 4, pp. 951–956, 2016, [Online]. Available: https://sid.ir/paper/289061/en

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