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Information Journal Paper

Title

Design and Synthesis of Pyrrolo[2, 1-a]Isoquinoline-Based Derivatives as New Cytotoxic Agents

Pages

  743-751

Keywords

2 
5 
6 
dihydropyrrolo[2 
1 

Abstract

 A new series of anti-cancer agents based on 1, 2-diaryl-5, 6-dihydropyrrolo[2, 1-a]isoquinoline scaffold containing N, N-diethylaminoethoxy, piperidinylethoxy or morpholinylethoxy group at the para position of the C-2 phenyl ring were synthesized and their cytotoxic activities were assessed against several human cancer cell lines including MCF-7 (ER positive breast cancer cell), MDA-MB231 (ER-negative breast cancer cell), T47D (Human ductal breast epithelial tumor cell line), A549 (adenocarcinomic human alveolar basal epithelial cells), and Hela (human cervix adenocarcinoma cells) using MTT assay. Based on results, compounds, 1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-5, 6-dihydro-8, 9-dimethoxy-2-phenylpyrrolo[2, 1-a]isoquinoline (6a) and 2-(4-(5, 6-dihydro-8, 9-dimethoxy-2-phenylpyrrolo[2, 1-a] isoquinolin-1-yl)phenoxy)-N, N-diethylethanamine (6c) were the most potent cytotoxic compounds and more toxic than the reference compound against T47D cell line, while all the compounds had satisfactory activity against HeLa cell line with mean IC50 values ranging from 1. 93 to 33. 84 μ M.

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    APA: Copy

    KAKHKI, SAMANEH, Shahosseini, Soraya, & ZARGHI, AFSHIN. (2016). Design and Synthesis of Pyrrolo[2, 1-a]Isoquinoline-Based Derivatives as New Cytotoxic Agents. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(4), 743-751. SID. https://sid.ir/paper/289063/en

    Vancouver: Copy

    KAKHKI SAMANEH, Shahosseini Soraya, ZARGHI AFSHIN. Design and Synthesis of Pyrrolo[2, 1-a]Isoquinoline-Based Derivatives as New Cytotoxic Agents. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(4):743-751. Available from: https://sid.ir/paper/289063/en

    IEEE: Copy

    SAMANEH KAKHKI, Soraya Shahosseini, and AFSHIN ZARGHI, “Design and Synthesis of Pyrrolo[2, 1-a]Isoquinoline-Based Derivatives as New Cytotoxic Agents,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 4, pp. 743–751, 2016, [Online]. Available: https://sid.ir/paper/289063/en

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