Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial

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SHEIKHMOONESI FATEMEH; ZARGHAMI MEHRAN; Mamashli Shima; YAZDANI CHARATI JAMSHID; Hamzehpour Romina; FATTAHI SAMINEH; Azadbakht Rahil; KASHI ZAHRA; ALA SHAHRAM; Moshayedi Mona; Alinia Habibollah; Hendouei Narjes

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:4 Page(s): 941-950

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Title

Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial

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Keywords

Vitamin D deficiency;

PANSS negative subscale score;

PANSS positive subscale score Positive;

Schizophrenic patients;

Antipsychotic drugs

Abstract

In this study, the aim was to determine whether adding vitamin D to the standard therapeutic regimen of schizophrenic male patients with inadequate vitamin D status could improve some aspects of the symptom burden or not. This study was an open parallel label randomized clinical trial. Eighty patients with chronic stable schizophrenia with residual symptoms and Vitamin D deficiency were recruited randomly and then received either 600000 IU Vitamin D injection once along with their antipsychotic regimen or with their antipsychotic regimen only. Serum vitamin D was measured twice: first at the baseline and again on the fourth month. Positive and Negative Syndrome Scale (PANSS) was assessed at the baseline and on the fourth month. During the study, the vitamin D serum changes in vitamin group and control group were 22. 1 ± 19. 9(95%CI = 15. 9-28. 8) and 0. 2 ± 1. 7(95%CI = 0. 2-0. 8) (ng/mL) (p<0. 001) respectively. The changes of PANSS positive subscale score (P) were-0. 1± 0. 7 (95%CI =-0. 3-0. 1) and 0. 00 ± 0. 8 (95%CI =-0. 2-0. 2) in vitamin D and control group respectively (p=0. 5). The changes of PANSS negative subscale score (N) were-0. 1 ± 0. 7 (95%CI =-0. 3-0. 05) and-0. 1 ± 0. 5 (95%CI =-0. 2-0. 04) in vitamin D and control group respectively (p = 0. 7) and there was a negative but not significant correlation between serum vitamin D level changes and PANSS negative subscale score (r =-0. 04, p = 0. 7). We did not find a relationship between serum vitamin D level changes and the improvement of negative and positive symptoms in schizophrenic patients and more randomized clinical trials are required to confirm our findings.

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APA: Copy

SHEIKHMOONESI, FATEMEH, ZARGHAMI, MEHRAN, Mamashli, Shima, YAZDANI CHARATI, JAMSHID, Hamzehpour, Romina, FATTAHI, SAMINEH, Azadbakht, Rahil, KASHI, ZAHRA, ALA, SHAHRAM, Moshayedi, Mona, Alinia, Habibollah, & Hendouei, Narjes. (2016). Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(4), 941-950. SID. https://sid.ir/paper/289081/en

Vancouver: Copy

SHEIKHMOONESI FATEMEH, ZARGHAMI MEHRAN, Mamashli Shima, YAZDANI CHARATI JAMSHID, Hamzehpour Romina, FATTAHI SAMINEH, Azadbakht Rahil, KASHI ZAHRA, ALA SHAHRAM, Moshayedi Mona, Alinia Habibollah, Hendouei Narjes. Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(4):941-950. Available from: https://sid.ir/paper/289081/en

IEEE: Copy

FATEMEH SHEIKHMOONESI, MEHRAN ZARGHAMI, Shima Mamashli, JAMSHID YAZDANI CHARATI, Romina Hamzehpour, SAMINEH FATTAHI, Rahil Azadbakht, ZAHRA KASHI, SHAHRAM ALA, Mona Moshayedi, Habibollah Alinia, and Narjes Hendouei, “Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 4, pp. 941–950, 2016, [Online]. Available: https://sid.ir/paper/289081/en

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