Anti-tumor Effect of Ginkgo biloba Exocarp Extracts on B16 Melanoma Bearing Mice Involving P I3K/Akt/HIF-1α /VEGF Signaling Pathways

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Cao Chen jie; Su Ya; SUN JIAN; Wang Gui yun; Jia Xiao qin; Chen Hua sheng; Xu Ai hua

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:2 Page(s): 803-811

Download Full-Text

View:

205

Download:

131

Cites:

Information Journal Paper

Title

Anti-tumor Effect of Ginkgo biloba Exocarp Extracts on B16 Melanoma Bearing Mice Involving P I3K/Akt/HIF-1α /VEGF Signaling Pathways

Author(s)

Keywords

Ginkgo biloba exocarp extracts

Melanoma

Angiogenesis

PI3K/Akt

HIF-1α

VEGF

Abstract

The objective of this study is to investigate the anti-tumor effect of Ginkgo biloba exocarp extracts (GBEE) on B16 Melanoma bearing mice and its related molecular mechanisms. The B16-F10 Melanoma solid tumor model was established in C57BL/6J mice. The tumor-bearing mice were treated with GBEE (50, 100, 200 mg/kg), taking cis-Dichlorodiamineplatinum (Ⅱ ) (DDP, 3 mg/kg) as positive control and normal saline (NS) as model control. After 17 days of administration, the transplanted tumors was stripped and weighed, and the inhibition rate was calculated. Quantitative Reverse Transcription Polymerase chain reaction (qRT-PCR), Western Blot and immunohistochemistry were applied to detect mRNA and protein levels of related factors in B16 transplanted tumor tissues. The results indicated that GBEE (50, 100, 200 mg/ kg) inhibited the growth of B16 transplanted solid tumor in C57BL/6J mice. Meanwhile, it inhibited the expression of CD34 and reduced microvessel density (MVD) in a dose-dependent manner. Moreover, GBEE dose-dependently down-regulated the mRNA and protein levels of hypoxia inducible factor-1α (HIF-1α; ), vascular endothelial growth factor (VEGF), and vascular endothelial growth factor receptor 2 (VEGFR2). The phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) proteins were not changed obviously, but the protein levels of p-PI3K and p-Akt were down-regulated. Overall, the inhibitory effect of GBEE on the growth of B16 Melanoma transplant tumor in mice is related to inhibiting Angiogenesis, and the mechanism involves the regulation of PI3K/Akt/ HIF-lα /VEGF signaling pathway.

Cites

No record.

References

No record.

Cite

APA: Copy

Cao, Chen jie, Su, Ya, SUN, JIAN, Wang, Gui yun, Jia, Xiao qin, Chen, Hua sheng, & Xu, Ai hua. (2019). Anti-tumor Effect of Ginkgo biloba Exocarp Extracts on B16 Melanoma Bearing Mice Involving P I3K/Akt/HIF-1α /VEGF Signaling Pathways. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(2), 803-811. SID. https://sid.ir/paper/289087/en

Vancouver: Copy

Cao Chen jie, Su Ya, SUN JIAN, Wang Gui yun, Jia Xiao qin, Chen Hua sheng, Xu Ai hua. Anti-tumor Effect of Ginkgo biloba Exocarp Extracts on B16 Melanoma Bearing Mice Involving P I3K/Akt/HIF-1α /VEGF Signaling Pathways. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(2):803-811. Available from: https://sid.ir/paper/289087/en

IEEE: Copy

Chen jie Cao, Ya Su, JIAN SUN, Gui yun Wang, Xiao qin Jia, Hua sheng Chen, and Ai hua Xu, “Anti-tumor Effect of Ginkgo biloba Exocarp Extracts on B16 Melanoma Bearing Mice Involving P I3K/Akt/HIF-1α /VEGF Signaling Pathways,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 2, pp. 803–811, 2019, [Online]. Available: https://sid.ir/paper/289087/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops