Aquaretic Activity of Solidago canadensis L. Cultivated in Egypt and Determination of the Most Bioactive Fraction

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Abdel Baki Passent Mahmoud; El Sherei Moshera Mohamed; Khaleel Amal Elsayed; Amira Ahmed Abdel Motaal; Ibrahim Abdallah Heba Mohammed

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:2 Page(s): 922-937

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Title

Aquaretic Activity of Solidago canadensis L. Cultivated in Egypt and Determination of the Most Bioactive Fraction

Author(s)

Keywords

Aquaretic activity

Flavonoids

Kaempferol-3-O-β

-ᴅ

-apiofuranoside

Phenolics

Saponins

Thymidine

Abstract

Despite the traditional use of Solidago canadensis L. (Asteraceae) as a diuretic drug, there is a scarcity in scientific data concerning the activity of its different extracts and fractions as well as the class of constituents responsible for this diuretic action. A comparative study was carried out for the diuretic activities of the different standardized extracts and fractions of the flowering aerial parts of S. canadensis, as well as isolation of compounds from the most biologically active fraction. The ethanol extract and its ethyl acetate fraction (EA) showed the highest aquaretic activities (91 and 58% at a dose of 400 mg/Kg b. wt., respectively) compared to 100% of furosemide at 20 mg/Kg b. wt. . Their activities were higher than Cystinol® and spironolactone reference standards (74% and 59% of furosemide, respectively). EA showed the highest total phenolic and flavonoid contents among the tested fractions of the ethanol and aqueous extracts (9. 38 ± 0. 004 g GAE and 39. 75 ± 0. 005 g RE/100 g dried extract, respectively). Eight Flavonoids, 2 phenolic acids and 1 nucleoside were isolated from EA. This is the first report of a comparative study between the aquaretic activities of the different extracts, fractions and essential oil of S. canadensis, as well as isolation of thyimidine (1), isorhamnetin-3-O-β-ᴅ;-glucopyranoside (2), kaempferol-3-O-(6”-O-acetyl)-β-ᴅ;-glucopyranoside (4), quercetin-3-O-(6”-O-acetyl)-β-ᴅ;-glucopyranoside (5), and Kaempferol-3-O-β;-ᴅ;-apiofuranoside (7) from genus Solidago.

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APA: Copy

Abdel Baki, Passent Mahmoud, El Sherei, Moshera Mohamed, Khaleel, Amal Elsayed, Amira Ahmed, Abdel Motaal, & Ibrahim Abdallah, Heba Mohammed. (2019). Aquaretic Activity of Solidago canadensis L. Cultivated in Egypt and Determination of the Most Bioactive Fraction. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(2), 922-937. SID. https://sid.ir/paper/289093/en

Vancouver: Copy

Abdel Baki Passent Mahmoud, El Sherei Moshera Mohamed, Khaleel Amal Elsayed, Amira Ahmed Abdel Motaal, Ibrahim Abdallah Heba Mohammed. Aquaretic Activity of Solidago canadensis L. Cultivated in Egypt and Determination of the Most Bioactive Fraction. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(2):922-937. Available from: https://sid.ir/paper/289093/en

IEEE: Copy

Passent Mahmoud Abdel Baki, Moshera Mohamed El Sherei, Amal Elsayed Khaleel, Abdel Motaal Amira Ahmed, and Heba Mohammed Ibrahim Abdallah, “Aquaretic Activity of Solidago canadensis L. Cultivated in Egypt and Determination of the Most Bioactive Fraction,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 2, pp. 922–937, 2019, [Online]. Available: https://sid.ir/paper/289093/en

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