Purification of Sesquiterpenes from Saussurea Lappa Roots by High Speed Counter Current Chromatography

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Cao Kun; Qian Wei; XU YI; Zhou Zhen

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1499-1507

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Information Journal Paper

Title

Purification of Sesquiterpenes from Saussurea Lappa Roots by High Speed Counter Current Chromatography

Author(s)

Cao Kun | Qian Wei | XU YI | Zhou Zhen | Issue Writer Certificate

Keywords

Saussurea lappa Roots

Sesquiterpenes lactones

Select solvent system

HSCCC

Orthogonal test

Abstract

Sesquiterpenes lactones including costunolide and dehydrocostus lactone, were isolated from Saussurea lappa Roots, which had exhibited a wide range of biological activities such as anti-cancer, anti-inflammatory, antiulcer, and immunomodulatory activities. High-speed counter-current chromatography (HSCCC) was applied for the rapid preparative isolation of Sesquiterpenes lactones from Saussurea lappa Roots. A solvent optimization method for HSCCC was presented, i. e. the separation factors of compounds after the partition coefficient (K) of solvent system should be investigated. Using this method, 150 mg of costunolide, 140 mg of dehydrocostus and 15 mg of 10-methoxy-artemisinic acid with purities of 95%, 98%, and 98% were obtained within 150 min. The structures of three compounds were identified by mass spectrum (MS) and nuclear magnetic resonance (NMR) spectroscopy. These results offered an efficient strategy for separation of potentially health-relevant phytochemicals from Saussurea lappa Roots.

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APA: Copy

Cao, Kun, Qian, Wei, & Zhou, Zhen. (2019). Purification of Sesquiterpenes from Saussurea Lappa Roots by High Speed Counter Current Chromatography. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1499-1507. SID. https://sid.ir/paper/289138/en

Vancouver: Copy

Cao Kun, Qian Wei, Zhou Zhen. Purification of Sesquiterpenes from Saussurea Lappa Roots by High Speed Counter Current Chromatography. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1499-1507. Available from: https://sid.ir/paper/289138/en

IEEE: Copy

Kun Cao, Wei Qian, and Zhen Zhou, “Purification of Sesquiterpenes from Saussurea Lappa Roots by High Speed Counter Current Chromatography,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1499–1507, 2019, [Online]. Available: https://sid.ir/paper/289138/en

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