Carvacrol Ameliorates Pathological Cardiac Hypertrophy in Both In-vivo and In-vitro Models

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Jamhiri Mohabbat; Safi Dahaj Farzan; ASTANI AKRAM; Hejazian Seyed Hasan; HAFIZIBARJIN ZEYNAB; GHOBADI MOJTABA; MORADI ALI; Khoradmehr Arezu; SAFARI FATEMEH

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1380-1394

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Title

Carvacrol Ameliorates Pathological Cardiac Hypertrophy in Both In-vivo and In-vitro Models

Author(s)

Keywords

Cardiac hypertrophy

Carvacrol

Rat

H9c2 cells

Blood pressure

Antioxidant

Apoptosis

Abstract

Hypertension-induced left ventricular hypertrophy is the most important risk factor for heart failure. This study aimed at investigating the effects of monoterpenoid phenol, Carvacrol, on myocardial hypertrophy using both in-vivo and in-vitro models. Male Wistar Rats were divided into the control (Ctl), un-treated hypertrophy (H), and Carvacrol-treated hypertrophy groups (25, 50 and 75 mg/kg/day, Car+H). In the hypertrophy groups animals underwent abdominal aorta banding. Blood pressure (BP) was recorded via carotid artery cannulation. TUNEL assay and Masson’ s trichrome staining were used to assess Apoptosis and fibrosis, respectively. The 2-2-diphenyl 1-picril-hydrasil )DPPH( radical scavenging activity and malondialdehyde (MDA) level were estimated by biochemical tests. In in-vitro study H9c2 cardiomyoblasts were treated with angiotensin II (Ang II) to promote hypertrophy. Cell size was measured using crystal violet staining. Gene expression was evaluated by real-time RT-PCR technique. In the Carvacrol-treated Rats BP, heart Rate, and heart weight to the body weight Ratio were significantly decreased. In-vitro study showed that H9c2 cell size was significantly reduced compared to Ang II-treated cells. Both in-vivo and in-vitro studies demonstRated that Carvacrol decreased atrial natriuretic peptide )ANP( mRNA level significantly (vs. H groups). The number of apoptotic cells increased in H group, while it was decreased in the Car50+H and Car75+H. In Car+H groups, in comparison with H group, the serum concentRation of MDA was decreased and DPPH was increased significantly. Our findings demonstRated that Carvacrol decreases hypertrophy markers in in-vivo and in-vitro models of hypertrophy.

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APA: Copy

Jamhiri, Mohabbat, Safi Dahaj, Farzan, ASTANI, AKRAM, Hejazian, Seyed Hasan, HAFIZIBARJIN, ZEYNAB, GHOBADI, MOJTABA, MORADI, ALI, Khoradmehr, Arezu, & SAFARI, FATEMEH. (2019). Carvacrol Ameliorates Pathological Cardiac Hypertrophy in Both In-vivo and In-vitro Models. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1380-1394. SID. https://sid.ir/paper/289171/en

Vancouver: Copy

Jamhiri Mohabbat, Safi Dahaj Farzan, ASTANI AKRAM, Hejazian Seyed Hasan, HAFIZIBARJIN ZEYNAB, GHOBADI MOJTABA, MORADI ALI, Khoradmehr Arezu, SAFARI FATEMEH. Carvacrol Ameliorates Pathological Cardiac Hypertrophy in Both In-vivo and In-vitro Models. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1380-1394. Available from: https://sid.ir/paper/289171/en

IEEE: Copy

Mohabbat Jamhiri, Farzan Safi Dahaj, AKRAM ASTANI, Seyed Hasan Hejazian, ZEYNAB HAFIZIBARJIN, MOJTABA GHOBADI, ALI MORADI, Arezu Khoradmehr, and FATEMEH SAFARI, “Carvacrol Ameliorates Pathological Cardiac Hypertrophy in Both In-vivo and In-vitro Models,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1380–1394, 2019, [Online]. Available: https://sid.ir/paper/289171/en

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