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Information Journal Paper

Title

Anticancer Activity of Polyisoprenoids from Avicennia alba Blume. in WiDr Cells

Pages

  1477-1487

Abstract

 Colorectal cancer is the third most common cancer world wide and has been occurred more in developing regions. The use of conventional chemotherapy agents may lead to various adverse effects. Therefore, it is required to find the potential drug for anticancer from alternative source of natural product including mangrove plants. The present study was conducted to determine the anticancer activity of Polyisoprenoids from Avicennia alba Blume. leaves (PAL) in WiDr cells. Cell cycle inhibition, Apoptosis activity, and suppression of cyclooxygenase-2 (COX-2) were also evaluated. The anticancer activity of PAL was determined by observing the activity of these compounds against WiDr cells using the [3-(4, 5-dimetiltiazol-2-il)-2, 5-difenil tetrazolium bromida] MTT assay. Inhibition of the Cell cycle and increased Apoptosis were analysed by flowcytometry. Suppression of COX-2 was analysed using immunocytochemistry. PAL exhibited anticancer activity against WiDr cells with an IC50 of 173. 775 μ g/mL. Cell cycle analysis revealed that the inhibition occurred in the G0-G1 phase, and Apoptosis occurred in the early Apoptosis phase. Furthermore, the result of an analysis of COX-2 expression showed that PAL enabled the suppression of COX-2 expression. PAL can be used as anticancer agents against WiDr colon cancer cells. However, in-vivo studies is required to confirm the in-vitro finding of the anticancer activity of polyisoprenoid extract.

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    • Cite

    APA: Copy

    Illian, Didi Nurhadi, Zaitun Hasibuan, Poppy Anjelisa, SUMARDI, SUMARDI, Nuryawan, Arif, Wati, Ridha, & Basyuni, Mohammad. (2019). Anticancer Activity of Polyisoprenoids from Avicennia alba Blume. in WiDr Cells. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1477-1487. SID. https://sid.ir/paper/289173/en

    Vancouver: Copy

    Illian Didi Nurhadi, Zaitun Hasibuan Poppy Anjelisa, SUMARDI SUMARDI, Nuryawan Arif, Wati Ridha, Basyuni Mohammad. Anticancer Activity of Polyisoprenoids from Avicennia alba Blume. in WiDr Cells. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1477-1487. Available from: https://sid.ir/paper/289173/en

    IEEE: Copy

    Didi Nurhadi Illian, Poppy Anjelisa Zaitun Hasibuan, SUMARDI SUMARDI, Arif Nuryawan, Ridha Wati, and Mohammad Basyuni, “Anticancer Activity of Polyisoprenoids from Avicennia alba Blume. in WiDr Cells,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1477–1487, 2019, [Online]. Available: https://sid.ir/paper/289173/en

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