Phytochemical Analysis and Various Biological Activities of the Aerial Parts of Scrophularia Atropatana Growing in Iran

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ASNAASHARI SOLMAZ; DELAZAR ABBAS; SAFARZADEH ELHAM; Tabibi Hamed; Mollaei Saeed; RAJABI ALI; ASGHARIAN PARINA

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1543-1555

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Title

Phytochemical Analysis and Various Biological Activities of the Aerial Parts of Scrophularia Atropatana Growing in Iran

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Keywords

Scrophularia atropatana

Phytochemical analysis

Biological activities

GC-MS analysis

MTT assay

Abstract

Scrophularia atropatana (S. atropatana), an Iranian plant belonging to the family of Scrophulariaceae, was assigned for its chemical compositions and Biological activities of essential oil (EO) and extracts of the aerial parts of the plant during the flowering stage. Combination of GC-MS and GC-FID was assessed for analyzing the chemical compositions of the EO from the aerial parts of S. atropatana. Furthermore, Brine shrimp lethality test and DPPH assay were performed to evaluate general toxicity and free-radical-scavenging properties, respectively. Furthermore, anti-proliferative and antimicrobial activities were assessed by MTT assay and disc diffusion methods correspondingly. Additionally, all the potent samples (extracts) and its fractions in the MTT assay were further studied for the presence of various compounds by GC-MS apparatus. MeOH extract and 40% sep-pak fraction indicated high amounts of total phenolic (TPC), total flavonoid content (TFC), and antioxidant properties. In the case of general toxicity, among the extracts, dichloromethane (DCM) extract showed noticeable effect. Furthermore, DCM extract was indicated potent ability to eliminate breast tumor cells and minimum efficacy on normal cells. Anti-microbial activity of all samples was ignorable. The potent extracts and fractions which had more anti-proliferative activity were further elucidated by GC-MS and showed high amounts of Alkanes and fatty acids. In the case of EO constituents, non-terpenoids were the major compounds. To sum up, it seems BSLT could be a good preliminary approach for evaluating the cytotoxicity in MCF-7 cell line. Additionally, antioxidant activity, TPC, and TFC contents of all samples were in consistent with each other.

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APA: Copy

ASNAASHARI, SOLMAZ, DELAZAR, ABBAS, SAFARZADEH, ELHAM, Tabibi, Hamed, Mollaei, Saeed, RAJABI, ALI, & ASGHARIAN, PARINA. (2019). Phytochemical Analysis and Various Biological Activities of the Aerial Parts of Scrophularia Atropatana Growing in Iran. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1543-1555. SID. https://sid.ir/paper/289178/en

Vancouver: Copy

ASNAASHARI SOLMAZ, DELAZAR ABBAS, SAFARZADEH ELHAM, Tabibi Hamed, Mollaei Saeed, RAJABI ALI, ASGHARIAN PARINA. Phytochemical Analysis and Various Biological Activities of the Aerial Parts of Scrophularia Atropatana Growing in Iran. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1543-1555. Available from: https://sid.ir/paper/289178/en

IEEE: Copy

SOLMAZ ASNAASHARI, ABBAS DELAZAR, ELHAM SAFARZADEH, Hamed Tabibi, Saeed Mollaei, ALI RAJABI, and PARINA ASGHARIAN, “Phytochemical Analysis and Various Biological Activities of the Aerial Parts of Scrophularia Atropatana Growing in Iran,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1543–1555, 2019, [Online]. Available: https://sid.ir/paper/289178/en

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