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Information Journal Paper

Title

Enhanced Solubility and Bioavailability of Apigenin via Preparation of Solid Dispersions of Mesoporous Silica Nanoparticles

Pages

  168-182

Abstract

 In this study, a novel Mesoporous silica nanoparticles drug carrier contributes to improving the Solubility, Dissolution, and the oral Bioavailability of Apigenin (AP). The Apigenin of Solid dispersion of Mesoporous silica nanoparticles (AP-MSN) was prepared by physical absorption method and also, in-vitro drug release and in-vivo Bioavailability performance were evaluated. Based on its Solubility, the AP-MSN Solid dispersion was prepared at the weight ratio of 1: 1 to obtain the optimum Solubility. The loading efficiency (LE), encapsulation efficiency (EE), and Solubility of AP-MSN Solid dispersion were 29. 71%, 42. 27%, and 25. 11 μ g/mL, respectively. SEM, TEM, BET, FTIR, XRD, DSC, and TG were also carried out. These results demonstrated that AP was good absorbed into the pores of MSN through physical absorption effect of MSN. The DMF residues of AP-MSN Solid dispersion meet the ICH requirements. It was vital that the AP-MSN Solid dispersion behaved well in-vitro and the accumulative release of AP-MSN Solid dispersion was 2. 37 times higher than that of raw AP. In-vivo study, the AP area under curve0-t was 8. 32 times higher for the AP-MSN Solid dispersion than that of raw AP, which indicated that the Bioavailability of AP-MSN Solid dispersion was greatly improved. Therefore, the prepared AP-MSN Solid dispersion presents potential as a novel oral therapeutic agent formulation for clinical application.

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    APA: Copy

    Huang, Yannian, Zhao, Xiuhua, Zu, Yuangang, Wang, Lu, Deng, Yiping, Wu, Mingfang, & Wang, Huimei. (2019). Enhanced Solubility and Bioavailability of Apigenin via Preparation of Solid Dispersions of Mesoporous Silica Nanoparticles. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 168-182. SID. https://sid.ir/paper/289192/en

    Vancouver: Copy

    Huang Yannian, Zhao Xiuhua, Zu Yuangang, Wang Lu, Deng Yiping, Wu Mingfang, Wang Huimei. Enhanced Solubility and Bioavailability of Apigenin via Preparation of Solid Dispersions of Mesoporous Silica Nanoparticles. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):168-182. Available from: https://sid.ir/paper/289192/en

    IEEE: Copy

    Yannian Huang, Xiuhua Zhao, Yuangang Zu, Lu Wang, Yiping Deng, Mingfang Wu, and Huimei Wang, “Enhanced Solubility and Bioavailability of Apigenin via Preparation of Solid Dispersions of Mesoporous Silica Nanoparticles,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 168–182, 2019, [Online]. Available: https://sid.ir/paper/289192/en

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