UPLC– ESI-PDA– Msn Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall. )

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Handoussa Heba; Abd Allah Walid; AbdelMohsen Mona

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:1 Page(s): 422-429

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Title

UPLC– ESI-PDA– Msn Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall. )

Author(s)

Handoussa Heba | Abd Allah Walid | AbdelMohsen Mona | Issue Writer Certificate

Keywords

Halocnemum strobilaceum

Phenolics

UPLC/PDA/ESI/MSn

Anticancer

Antioxidant

Abstract

Halocnemum strobilaceum is a halophyte present in the humid and arid bioclimatic regions of Egypt. The current study aimed at UPLC/PDA/ESI-MSn qualitative chemical profiling of the phyto-constituents underlining both Antioxidant and cytotoxic activities of the bio-active fraction in comparison with the other fractions. It resulted in detection of several related compounds to prenylated flavonol icariin as a first report in this species. Results showed that ethyl acetate exhibits an appreciable Antioxidant activity using in-vitro DPPH assay with percentage of 82. 35% and remarkable Anticancer capacity against most common types of cancer in Egypt; breast (MCF-7), human prostate (PC-3) cancer cell lines, and human lung carcinoma (A-549) with IC50 43. 1± 2 μ g/mL, 115± 5 μ g/ml, and 53. 3± 3 μ g/mL respectively. These findings point out the appropriate solvent for extraction of the bio-Phenolics with this halophyte which is a considerable source of remarkable potential secondary metabolites that exhibit original and interesting Anticancer capacity.

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APA: Copy

Handoussa, Heba, Abd Allah, Walid, & AbdelMohsen, Mona. (2019). UPLC– ESI-PDA– Msn Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall. ). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 422-429. SID. https://sid.ir/paper/289203/en

Vancouver: Copy

Handoussa Heba, Abd Allah Walid, AbdelMohsen Mona. UPLC– ESI-PDA– Msn Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall. ). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):422-429. Available from: https://sid.ir/paper/289203/en

IEEE: Copy

Heba Handoussa, Walid Abd Allah, and Mona AbdelMohsen, “UPLC– ESI-PDA– Msn Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall. ),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 422–429, 2019, [Online]. Available: https://sid.ir/paper/289203/en

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