Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities

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JARRAHPOUR ALIASGHAR; HEIRAN ROGHAYEH; Sinou Veronique; Latour Christine; Bouktab Lamia Djouhri; Brunel Jean Michel; SHEIKH JAVED; Hadda Taibi Ben

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:1 Page(s): 34-48

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Title

Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities

Author(s)

Keywords

-Lactam

2-Azetidinones

Acylation

Antimalarial activities

POM analyses

Abstract

Some new β;-Lactams bearing biologically important morpholine ring have been synthesized by Acylation of amino β;-Lactams in the presence of morpholine-4-carbonyl chloride. These novel β;-Lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC50 values.

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APA: Copy

JARRAHPOUR, ALIASGHAR, HEIRAN, ROGHAYEH, Sinou, Veronique, Latour, Christine, Bouktab, Lamia Djouhri, Brunel, Jean Michel, SHEIKH, JAVED, & Hadda, Taibi Ben. (2019). Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 34-48. SID. https://sid.ir/paper/289213/en

Vancouver: Copy

JARRAHPOUR ALIASGHAR, HEIRAN ROGHAYEH, Sinou Veronique, Latour Christine, Bouktab Lamia Djouhri, Brunel Jean Michel, SHEIKH JAVED, Hadda Taibi Ben. Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):34-48. Available from: https://sid.ir/paper/289213/en

IEEE: Copy

ALIASGHAR JARRAHPOUR, ROGHAYEH HEIRAN, Veronique Sinou, Christine Latour, Lamia Djouhri Bouktab, Jean Michel Brunel, JAVED SHEIKH, and Taibi Ben Hadda, “Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 34–48, 2019, [Online]. Available: https://sid.ir/paper/289213/en

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